Microfluidic synthesis of rigid nanovesicles for hydrophilic reagents delivery

Lu Zhang; Qiang Feng; Jiuling Wang; Jiashu Sun; Xinghua Shi; Xingyu Jiang

doi:10.1002/anie.201500096

Microfluidic synthesis of rigid nanovesicles for hydrophilic reagents delivery

Lu Zhang, Qiang Feng, Jiuling Wang, Jiashu Sun, Xinghua Shi, Xingyu Jiang

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

We present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic-co-glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is ≈90 %. In comparison with the combination of free Dox and siRNA, RNV that co-encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti-tumor effect for a multi-drug resistant tumor model.

Original language	English
Pages (from-to)	3952-3956
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	13
DOIs	https://doi.org/10.1002/anie.201500096
Publication status	Published - 23 Mar 2015
Externally published	Yes

Keywords

drug delivery
hydrophilic reagents
microfluidics
nanoparticles
vesicles

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abstract = "We present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic-co-glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is ≈90 %. In comparison with the combination of free Dox and siRNA, RNV that co-encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti-tumor effect for a multi-drug resistant tumor model.",

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AU - Zhang, Lu

AU - Feng, Qiang

AU - Wang, Jiuling

AU - Sun, Jiashu

AU - Shi, Xinghua

AU - Jiang, Xingyu

PY - 2015/3/23

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KW - hydrophilic reagents

KW - microfluidics

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Microfluidic synthesis of rigid nanovesicles for hydrophilic reagents delivery

Abstract

Keywords

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