Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel

Pengyun Li; Xiaoming Liu; Xiaoqing Tang; Yuqing Lin; Masaru Kojima; Qiang Huang; Tatsuo Arai

doi:10.1109/CBS.2018.8612154

Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel

Pengyun Li
, Xiaoming Liu
, Xiaoqing Tang
, Yuqing Lin
, Masaru Kojima
, Qiang Huang
, Tatsuo Arai

School of Mechatronical Engineering

Beijing Institute of Technology
The University of Osaka

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.

Original language	English
Title of host publication	2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	88-92
Number of pages	5
ISBN (Electronic)	9781538673553
DOIs	https://doi.org/10.1109/CBS.2018.8612154
Publication status	Published - 2 Jul 2018
Event	2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018 - Shenzhen, China Duration: 25 Oct 2018 → 27 Oct 2018

Publication series

Name	2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018

Conference

Conference	2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018
Country/Territory	China
City	Shenzhen
Period	25/10/18 → 27/10/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/CBS.2018.8612154

Cite this

Li, P., Liu, X., Tang, X., Lin, Y., Kojima, M., Huang, Q., & Arai, T. (2018). Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel. In 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018 (pp. 88-92). Article 8612154 (2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CBS.2018.8612154

Li, Pengyun ; Liu, Xiaoming ; Tang, Xiaoqing et al. / Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel. 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 88-92 (2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018).

@inproceedings{a7253b9b0ffb4712affbc068e1af3b6b,

title = "Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel",

abstract = "This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.",

author = "Pengyun Li and Xiaoming Liu and Xiaoqing Tang and Yuqing Lin and Masaru Kojima and Qiang Huang and Tatsuo Arai",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018 ; Conference date: 25-10-2018 Through 27-10-2018",

year = "2018",

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doi = "10.1109/CBS.2018.8612154",

language = "English",

series = "2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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}

Li, P, Liu, X, Tang, X, Lin, Y, Kojima, M, Huang, Q & Arai, T 2018, Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel. in 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018., 8612154, 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018, Institute of Electrical and Electronics Engineers Inc., pp. 88-92, 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018, Shenzhen, China, 25/10/18. https://doi.org/10.1109/CBS.2018.8612154

Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel. / Li, Pengyun; Liu, Xiaoming; Tang, Xiaoqing et al.
2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 88-92 8612154 (2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel

AU - Li, Pengyun

AU - Liu, Xiaoming

AU - Tang, Xiaoqing

AU - Lin, Yuqing

AU - Kojima, Masaru

AU - Huang, Qiang

AU - Arai, Tatsuo

PY - 2018/7/2

Y1 - 2018/7/2

N2 - This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.

AB - This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.

UR - https://www.scopus.com/pages/publications/85062071046

U2 - 10.1109/CBS.2018.8612154

DO - 10.1109/CBS.2018.8612154

M3 - Conference contribution

AN - SCOPUS:85062071046

T3 - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018

SP - 88

EP - 92

BT - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018

Y2 - 25 October 2018 through 27 October 2018

ER -

Li P, Liu X, Tang X, Lin Y, Kojima M, Huang Q et al. Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel. In 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 88-92. 8612154. (2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018). doi: 10.1109/CBS.2018.8612154

Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel

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