TY - GEN
T1 - Microfluidic Device for Analyzing Self-adaption of Cancer Cell During Squeezing in channel
AU - Li, Pengyun
AU - Liu, Xiaoming
AU - Tang, Xiaoqing
AU - Lin, Yuqing
AU - Kojima, Masaru
AU - Huang, Qiang
AU - Arai, Tatsuo
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/7/2
Y1 - 2018/7/2
N2 - This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.
AB - This paper reports an improved method for applying the physical squeezing on cells inside a microfluidic device. It is reported that cancer cells can respond and adapt to extracellular environments in order to cross basement membranes and connective tissues. But, it is not clearly studied that how cancer cells respond and adapt to a confined environment. For this study, we design and develop a one-layer channel to simulate a confined migration environment, and it can apply repetitive and sequential physical squeezing processes to a number of cancer cells inside this microfluidic device. In experiment, every cancer cell suffers a total of 20 physical squeezing processes in channel, and we observed the deformation and adaption using high speed-camera under microscope and the preliminary result indicates that the passing time of cells passing through each row of channel is decreasing.
UR - http://www.scopus.com/inward/record.url?scp=85062071046&partnerID=8YFLogxK
U2 - 10.1109/CBS.2018.8612154
DO - 10.1109/CBS.2018.8612154
M3 - Conference contribution
AN - SCOPUS:85062071046
T3 - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018
SP - 88
EP - 92
BT - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2018 IEEE International Conference on Cyborg and Bionic Systems, CBS 2018
Y2 - 25 October 2018 through 27 October 2018
ER -
