Microdevice for magnetic cell separation simple fabrication and simulation analysis

O. Saeed, Yulin Deng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Rare cells separation from blood as in circulating tumor cells (CTCs) isolation and other cells from blood has fetal importance in disease monitoring and treatment. Here we study a method for cancer cells separation from patient blood or buffer sample by magnetic focusing technique. Magnetic and drag forces computational simulation and calculations been presented. The microfluidic device chractrization, was carried by using COMSOL Multiphysics 4.3a modeling software (COMSOL, Inc.) The simulation was carried out in two stages including magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and the cell/particle tracing for cell separation verifications. Separation with 98% purity and efficiency of the unwanted particle was achieved 0.105m/s velocity. Considering the results achieved and cancer cells size about 15 μm, our proposed microchannel device is a good candidate for cancer cells separation from blood/buffer.

Original languageEnglish
Title of host publicationIEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2006-2010
Number of pages5
ISBN (Electronic)9781538608135
DOIs
Publication statusPublished - 20 Jun 2018
Event2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017 - Chennai, India
Duration: 21 Sept 201722 Sept 2017

Publication series

NameIEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017

Conference

Conference2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017
Country/TerritoryIndia
CityChennai
Period21/09/1722/09/17

Keywords

  • CTCs
  • Cell Separation
  • Magnetophoresis

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