Microdevice for magnetic cell separation simple fabrication and simulation analysis

O. Saeed; Yulin Deng

doi:10.1109/ICPCSI.2017.8392066

Microdevice for magnetic cell separation simple fabrication and simulation analysis

O. Saeed
, Yulin Deng

School of Medical Technology

Beijing Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Rare cells separation from blood as in circulating tumor cells (CTCs) isolation and other cells from blood has fetal importance in disease monitoring and treatment. Here we study a method for cancer cells separation from patient blood or buffer sample by magnetic focusing technique. Magnetic and drag forces computational simulation and calculations been presented. The microfluidic device chractrization, was carried by using COMSOL Multiphysics 4.3a modeling software (COMSOL, Inc.) The simulation was carried out in two stages including magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and the cell/particle tracing for cell separation verifications. Separation with 98% purity and efficiency of the unwanted particle was achieved 0.105m/s velocity. Considering the results achieved and cancer cells size about 15 μm, our proposed microchannel device is a good candidate for cancer cells separation from blood/buffer.

Original language	English
Title of host publication	IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2006-2010
Number of pages	5
ISBN (Electronic)	9781538608135
DOIs	https://doi.org/10.1109/ICPCSI.2017.8392066
Publication status	Published - 20 Jun 2018
Event	2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017 - Chennai, India Duration: 21 Sept 2017 → 22 Sept 2017

Publication series

Name	IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017

Conference

Conference	2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017
Country/Territory	India
City	Chennai
Period	21/09/17 → 22/09/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CTCs
Cell Separation
Magnetophoresis

Access to Document

10.1109/ICPCSI.2017.8392066

Cite this

Saeed, O., & Deng, Y. (2018). Microdevice for magnetic cell separation simple fabrication and simulation analysis. In IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017 (pp. 2006-2010). (IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICPCSI.2017.8392066

Saeed, O. ; Deng, Yulin. / Microdevice for magnetic cell separation simple fabrication and simulation analysis. IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 2006-2010 (IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017).

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title = "Microdevice for magnetic cell separation simple fabrication and simulation analysis",

abstract = "Rare cells separation from blood as in circulating tumor cells (CTCs) isolation and other cells from blood has fetal importance in disease monitoring and treatment. Here we study a method for cancer cells separation from patient blood or buffer sample by magnetic focusing technique. Magnetic and drag forces computational simulation and calculations been presented. The microfluidic device chractrization, was carried by using COMSOL Multiphysics 4.3a modeling software (COMSOL, Inc.) The simulation was carried out in two stages including magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and the cell/particle tracing for cell separation verifications. Separation with 98\% purity and efficiency of the unwanted particle was achieved 0.105m/s velocity. Considering the results achieved and cancer cells size about 15 μm, our proposed microchannel device is a good candidate for cancer cells separation from blood/buffer.",

keywords = "CTCs, Cell Separation, Magnetophoresis",

author = "O. Saeed and Yulin Deng",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017 ; Conference date: 21-09-2017 Through 22-09-2017",

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language = "English",

series = "IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017",

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Saeed, O & Deng, Y 2018, Microdevice for magnetic cell separation simple fabrication and simulation analysis. in IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017. IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017, Institute of Electrical and Electronics Engineers Inc., pp. 2006-2010, 2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017, Chennai, India, 21/09/17. https://doi.org/10.1109/ICPCSI.2017.8392066

Microdevice for magnetic cell separation simple fabrication and simulation analysis. / Saeed, O.; Deng, Yulin.
IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017. Institute of Electrical and Electronics Engineers Inc., 2018. p. 2006-2010 (IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Microdevice for magnetic cell separation simple fabrication and simulation analysis

AU - Saeed, O.

AU - Deng, Yulin

PY - 2018/6/20

Y1 - 2018/6/20

N2 - Rare cells separation from blood as in circulating tumor cells (CTCs) isolation and other cells from blood has fetal importance in disease monitoring and treatment. Here we study a method for cancer cells separation from patient blood or buffer sample by magnetic focusing technique. Magnetic and drag forces computational simulation and calculations been presented. The microfluidic device chractrization, was carried by using COMSOL Multiphysics 4.3a modeling software (COMSOL, Inc.) The simulation was carried out in two stages including magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and the cell/particle tracing for cell separation verifications. Separation with 98% purity and efficiency of the unwanted particle was achieved 0.105m/s velocity. Considering the results achieved and cancer cells size about 15 μm, our proposed microchannel device is a good candidate for cancer cells separation from blood/buffer.

AB - Rare cells separation from blood as in circulating tumor cells (CTCs) isolation and other cells from blood has fetal importance in disease monitoring and treatment. Here we study a method for cancer cells separation from patient blood or buffer sample by magnetic focusing technique. Magnetic and drag forces computational simulation and calculations been presented. The microfluidic device chractrization, was carried by using COMSOL Multiphysics 4.3a modeling software (COMSOL, Inc.) The simulation was carried out in two stages including magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and the cell/particle tracing for cell separation verifications. Separation with 98% purity and efficiency of the unwanted particle was achieved 0.105m/s velocity. Considering the results achieved and cancer cells size about 15 μm, our proposed microchannel device is a good candidate for cancer cells separation from blood/buffer.

KW - CTCs

KW - Cell Separation

KW - Magnetophoresis

UR - https://www.scopus.com/pages/publications/85050156575

U2 - 10.1109/ICPCSI.2017.8392066

DO - 10.1109/ICPCSI.2017.8392066

M3 - Conference contribution

AN - SCOPUS:85050156575

T3 - IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017

SP - 2006

EP - 2010

BT - IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017

Y2 - 21 September 2017 through 22 September 2017

ER -

Saeed O, Deng Y. Microdevice for magnetic cell separation simple fabrication and simulation analysis. In IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017. Institute of Electrical and Electronics Engineers Inc. 2018. p. 2006-2010. (IEEE International Conference on Power, Control, Signals and Instrumentation Engineering, ICPCSI 2017). doi: 10.1109/ICPCSI.2017.8392066

Microdevice for magnetic cell separation simple fabrication and simulation analysis

Abstract

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UN SDGs

Keywords

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