Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles

Jingyi Zhang; Ying Li; Chaofeng Zhang; Xiao Na Wang; Junbiao Chang

doi:10.1021/acs.orglett.1c00158

Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles

Jingyi Zhang, Ying Li, Chaofeng Zhang, Xiao Na Wang^*, Junbiao Chang^*

^*Corresponding author for this work

Zhengzhou University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.

Original language	English
Pages (from-to)	2029-2035
Number of pages	7
Journal	Organic Letters
Volume	23
Issue number	6
DOIs	https://doi.org/10.1021/acs.orglett.1c00158
Publication status	Published - 19 Mar 2021
Externally published	Yes

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10.1021/acs.orglett.1c00158

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title = "Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles",

abstract = "A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.",

author = "Jingyi Zhang and Ying Li and Chaofeng Zhang and Wang, {Xiao Na} and Junbiao Chang",

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doi = "10.1021/acs.orglett.1c00158",

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AU - Zhang, Jingyi

AU - Li, Ying

AU - Zhang, Chaofeng

AU - Wang, Xiao Na

AU - Chang, Junbiao

N1 - Publisher Copyright: ©

PY - 2021/3/19

Y1 - 2021/3/19

N2 - A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.

AB - A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.

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U2 - 10.1021/acs.orglett.1c00158

DO - 10.1021/acs.orglett.1c00158

M3 - Article

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SN - 1523-7060

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JO - Organic Letters

JF - Organic Letters

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ER -

Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles

Abstract

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