Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

Mingmin Zhang; Yanfeng Wang; Jie Geng; Shuqin Zhou; Bailong Xiao

doi:10.1016/j.celrep.2019.01.056

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

Mingmin Zhang
, Yanfeng Wang
, Jie Geng
, Shuqin Zhou
, Bailong Xiao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Using conditional deletion of endogenously expressed Piezo2 or ectopic expression of Piezo1 in primary somatosensory neurons, Zhang et al. find that mechanically activated Piezo channels can mediate touch and proprioception as well as indirectly suppress acute mechanical pain responses in mice.

Original language	English
Pages (from-to)	1419-1431.e4
Journal	Cell Reports
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2019.01.056
Publication status	Published - 5 Feb 2019
Externally published	Yes

Keywords

DRG
mechanosensation
mechanosensitive ion channels
pain
Piezo1
Piezo2
proprioception
touch

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10.1016/j.celrep.2019.01.056

Cite this

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title = "Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice",

abstract = "Using conditional deletion of endogenously expressed Piezo2 or ectopic expression of Piezo1 in primary somatosensory neurons, Zhang et al. find that mechanically activated Piezo channels can mediate touch and proprioception as well as indirectly suppress acute mechanical pain responses in mice.",

keywords = "DRG, mechanosensation, mechanosensitive ion channels, pain, Piezo1, Piezo2, proprioception, touch",

author = "Mingmin Zhang and Yanfeng Wang and Jie Geng and Shuqin Zhou and Bailong Xiao",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

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T1 - Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

AU - Zhang, Mingmin

AU - Wang, Yanfeng

AU - Geng, Jie

AU - Zhou, Shuqin

AU - Xiao, Bailong

PY - 2019/2/5

Y1 - 2019/2/5

N2 - Using conditional deletion of endogenously expressed Piezo2 or ectopic expression of Piezo1 in primary somatosensory neurons, Zhang et al. find that mechanically activated Piezo channels can mediate touch and proprioception as well as indirectly suppress acute mechanical pain responses in mice.

AB - Using conditional deletion of endogenously expressed Piezo2 or ectopic expression of Piezo1 in primary somatosensory neurons, Zhang et al. find that mechanically activated Piezo channels can mediate touch and proprioception as well as indirectly suppress acute mechanical pain responses in mice.

KW - DRG

KW - mechanosensation

KW - mechanosensitive ion channels

KW - pain

KW - Piezo1

KW - Piezo2

KW - proprioception

KW - touch

UR - https://www.scopus.com/pages/publications/85060543040

U2 - 10.1016/j.celrep.2019.01.056

DO - 10.1016/j.celrep.2019.01.056

M3 - Article

C2 - 30726728

AN - SCOPUS:85060543040

SN - 2211-1247

VL - 26

SP - 1419-1431.e4

JO - Cell Reports

JF - Cell Reports

IS - 6

ER -

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

Abstract

Keywords

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