Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

Qian Cai; Yue Fei; Hong Wei An; Xiao Xiao Zhao; Yang Ma; Yong Cong; Liming Hu; Li Li Li; Hao Wang

doi:10.1021/acsami.7b19056

Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

Qian Cai
, Yue Fei
, Hong Wei An
, Xiao Xiao Zhao
, Yang Ma
, Yong Cong
, Liming Hu^*
, Li Li Li
, Hao Wang

^*Corresponding author for this work

Beijing University of Technology
National Center for Nanoscience and Technology

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with "sandwich" dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

Original language	English
Pages (from-to)	9197-9202
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	10
Issue number	11
DOIs	https://doi.org/10.1021/acsami.7b19056
Publication status	Published - 21 Mar 2018
Externally published	Yes

Keywords

antibacterial agent
chlorophyll
infection
peptide
photodynamic therapy

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10.1021/acsami.7b19056

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title = "Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers",

abstract = "The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with {"}sandwich{"} dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.",

keywords = "antibacterial agent, chlorophyll, infection, peptide, photodynamic therapy",

author = "Qian Cai and Yue Fei and An, \{Hong Wei\} and Zhao, \{Xiao Xiao\} and Yang Ma and Yong Cong and Liming Hu and Li, \{Li Li\} and Hao Wang",

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year = "2018",

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doi = "10.1021/acsami.7b19056",

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T1 - Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

AU - Cai, Qian

AU - Fei, Yue

AU - An, Hong Wei

AU - Zhao, Xiao Xiao

AU - Ma, Yang

AU - Cong, Yong

AU - Hu, Liming

AU - Li, Li Li

AU - Wang, Hao

PY - 2018/3/21

Y1 - 2018/3/21

N2 - The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with "sandwich" dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

AB - The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with "sandwich" dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

KW - antibacterial agent

KW - chlorophyll

KW - infection

KW - peptide

KW - photodynamic therapy

UR - https://www.scopus.com/pages/publications/85044175667

U2 - 10.1021/acsami.7b19056

DO - 10.1021/acsami.7b19056

M3 - Article

C2 - 29443494

AN - SCOPUS:85044175667

SN - 1944-8244

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JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 11

ER -

Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers

Abstract

Keywords

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