Lipid droplets imaging with three-photon microscopy

Mubin He; Hojeong Park; Guangle Niu; Qiming Xia; Hequn Zhang; Ben Zhong Tang; Jun Qian

doi:10.1142/S179354582250033X

Lipid droplets imaging with three-photon microscopy

Mubin He
, Hojeong Park
, Guangle Niu
, Qiming Xia
, Hequn Zhang
, Ben Zhong Tang^*
, Jun Qian^*

^*Corresponding author for this work

Zhejiang University
Hong Kong University of Science and Technology
Shandong University
Sir Run Run Shaw Hospital
The Chinese University of Hong Kong, Shenzhen

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 (1.67×10-79cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80μm. Fat liver diagnosis was successfully carried out with excellent performance, providing great potential for LDs-associated pathologies research.

Original language	English
Article number	2250033
Journal	Journal of Innovative Optical Health Sciences
Volume	16
Issue number	4
DOIs	https://doi.org/10.1142/S179354582250033X
Publication status	Published - 1 Jul 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lipid droplets
deep-tissue imaging
fat liver
three-photon fluorescence microscopy

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10.1142/S179354582250033X

Cite this

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title = "Lipid droplets imaging with three-photon microscopy",

abstract = "Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 (1.67×10-79cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80μm. Fat liver diagnosis was successfully carried out with excellent performance, providing great potential for LDs-associated pathologies research.",

keywords = "Lipid droplets, deep-tissue imaging, fat liver, three-photon fluorescence microscopy",

author = "Mubin He and Hojeong Park and Guangle Niu and Qiming Xia and Hequn Zhang and Tang, \{Ben Zhong\} and Jun Qian",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s).",

year = "2023",

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doi = "10.1142/S179354582250033X",

language = "English",

volume = "16",

journal = "Journal of Innovative Optical Health Sciences",

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TY - JOUR

T1 - Lipid droplets imaging with three-photon microscopy

AU - He, Mubin

AU - Park, Hojeong

AU - Niu, Guangle

AU - Xia, Qiming

AU - Zhang, Hequn

AU - Tang, Ben Zhong

AU - Qian, Jun

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 (1.67×10-79cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80μm. Fat liver diagnosis was successfully carried out with excellent performance, providing great potential for LDs-associated pathologies research.

AB - Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 (1.67×10-79cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80μm. Fat liver diagnosis was successfully carried out with excellent performance, providing great potential for LDs-associated pathologies research.

KW - Lipid droplets

KW - deep-tissue imaging

KW - fat liver

KW - three-photon fluorescence microscopy

UR - https://www.scopus.com/pages/publications/85140756222

U2 - 10.1142/S179354582250033X

DO - 10.1142/S179354582250033X

M3 - Article

AN - SCOPUS:85140756222

SN - 1793-5458

VL - 16

JO - Journal of Innovative Optical Health Sciences

JF - Journal of Innovative Optical Health Sciences

IS - 4

M1 - 2250033

ER -

Lipid droplets imaging with three-photon microscopy

Abstract

UN SDGs

Keywords

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