Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides

Cheng Niu; Dong Hua Xie; Da Ming Du

doi:10.1039/d2qo01023b

Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides

Cheng Niu
, Dong Hua Xie
, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and α,β-unsaturated anhydrides was developed for the first time. In the presence of a 10 mol% isothiourea catalyst, various benzothienopyridinones were afforded in good to excellent yields (73-96%) with excellent enantioselectivities (up to 98 : 2 er).

Original language	English
Pages (from-to)	5551-5556
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	9
Issue number	20
DOIs	https://doi.org/10.1039/d2qo01023b
Publication status	Published - 26 Aug 2022

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title = "Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides",

abstract = "An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and α,β-unsaturated anhydrides was developed for the first time. In the presence of a 10 mol\% isothiourea catalyst, various benzothienopyridinones were afforded in good to excellent yields (73-96\%) with excellent enantioselectivities (up to 98 : 2 er).",

author = "Cheng Niu and Xie, \{Dong Hua\} and Du, \{Da Ming\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

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doi = "10.1039/d2qo01023b",

language = "English",

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T1 - Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides

AU - Niu, Cheng

AU - Xie, Dong Hua

AU - Du, Da Ming

PY - 2022/8/26

Y1 - 2022/8/26

N2 - An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and α,β-unsaturated anhydrides was developed for the first time. In the presence of a 10 mol% isothiourea catalyst, various benzothienopyridinones were afforded in good to excellent yields (73-96%) with excellent enantioselectivities (up to 98 : 2 er).

AB - An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and α,β-unsaturated anhydrides was developed for the first time. In the presence of a 10 mol% isothiourea catalyst, various benzothienopyridinones were afforded in good to excellent yields (73-96%) with excellent enantioselectivities (up to 98 : 2 er).

UR - https://www.scopus.com/pages/publications/85138608992

U2 - 10.1039/d2qo01023b

DO - 10.1039/d2qo01023b

M3 - Article

AN - SCOPUS:85138608992

SN - 2052-4110

VL - 9

SP - 5551

EP - 5556

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 20

ER -

Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides

Abstract

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