Isolation and structural identification of lignans from Dregea sinensis Hemsl

Shao Hua Jia; Fang Lü; Rong Ji Dai; Wei Wei Meng; Yan Chen; Yu Lin Deng

doi:10.15918/j.tbit1001-0645.2015.03.021

Isolation and structural identification of lignans from Dregea sinensis Hemsl

Shao Hua Jia
, Fang Lü^*
, Rong Ji Dai
, Wei Wei Meng
, Yan Chen
, Yu Lin Deng

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

Original language	English
Pages (from-to)	326-330
Number of pages	5
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	35
Issue number	3
DOIs	https://doi.org/10.15918/j.tbit1001-0645.2015.03.021
Publication status	Published - 1 Mar 2015

Keywords

Asclepiadaceae
Constituent
Dregea sinensis Hemsl
Lignans
Structure identification

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10.15918/j.tbit1001-0645.2015.03.021

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title = "Isolation and structural identification of lignans from Dregea sinensis Hemsl",

abstract = "In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.",

keywords = "Asclepiadaceae, Constituent, Dregea sinensis Hemsl, Lignans, Structure identification",

author = "Jia, \{Shao Hua\} and Fang L{\"u} and Dai, \{Rong Ji\} and Meng, \{Wei Wei\} and Yan Chen and Deng, \{Yu Lin\}",

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T1 - Isolation and structural identification of lignans from Dregea sinensis Hemsl

AU - Jia, Shao Hua

AU - Lü, Fang

AU - Dai, Rong Ji

AU - Meng, Wei Wei

AU - Chen, Yan

AU - Deng, Yu Lin

PY - 2015/3/1

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N2 - In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

AB - In order to study the chemical constituents of Dregea sinensis Hemsl, five lignans were isolated from the roots of Dregea sinensis Hemsl by AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. On the basis of 1D and 2D NMR data and MS analyses, their structures were identified as 4', 4″-dihydroxy-3,3', 3″, 5,5', 5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″, 9″-diol (1), 4',4″-dihydroxy-3,3', 3″, 5, 5'-pentamethoxy-7,9':7', 9-diepoxy-4,8″-oxy-8,8'-sesquineo-lignan-7″, 9″-diol (2), (+)-isolariciresinol (3), erythro-guaiacylycerol-β-O-4'-coniferyl alcohol (4), diasyringaresinol (5). These compounds were isolated from this plant for the first time.

KW - Asclepiadaceae

KW - Constituent

KW - Dregea sinensis Hemsl

KW - Lignans

KW - Structure identification

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JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

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ER -

Isolation and structural identification of lignans from Dregea sinensis Hemsl

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Keywords

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