TY - JOUR
T1 - Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids
AU - Yang, Pengfei
AU - Li, Jin
AU - Zhang, Tianyi
AU - Ren, Yanxian
AU - Zhang, Qiuning
AU - Liu, Ruifeng
AU - Li, Haining
AU - Hua, Junrui
AU - Wang, Wen An
AU - Wang, Jufang
AU - Zhou, Heng
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.
PY - 2023/11
Y1 - 2023/11
N2 - Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related. Ionizing radiation is a frequently used cancer therapy to kill malignancies. We found that ionizing radiation induces both ferroptosis and autophagy and that there is a form of mutualism between the two processes. Ionizing radiation also causes lipid droplets to form in proximity to damaged mitochondria, which, through the action of mitophagy, results in the degradation of the peridroplet mitochondria by lysosomes and the consequent release of free fatty acids and a significant increase in lipid peroxidation, thus promoting ferroptosis. Ionizing radiation has a stronger, fatal effect on cells with a high level of mitophagy, and this observation suggests a novel strategy for tumor treatment.
AB - Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related. Ionizing radiation is a frequently used cancer therapy to kill malignancies. We found that ionizing radiation induces both ferroptosis and autophagy and that there is a form of mutualism between the two processes. Ionizing radiation also causes lipid droplets to form in proximity to damaged mitochondria, which, through the action of mitophagy, results in the degradation of the peridroplet mitochondria by lysosomes and the consequent release of free fatty acids and a significant increase in lipid peroxidation, thus promoting ferroptosis. Ionizing radiation has a stronger, fatal effect on cells with a high level of mitophagy, and this observation suggests a novel strategy for tumor treatment.
UR - http://www.scopus.com/inward/record.url?scp=85174050761&partnerID=8YFLogxK
U2 - 10.1038/s41418-023-01230-0
DO - 10.1038/s41418-023-01230-0
M3 - Article
C2 - 37828085
AN - SCOPUS:85174050761
SN - 1350-9047
VL - 30
SP - 2432
EP - 2445
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 11
ER -
