Investigation of β-CD-derivatized erythromycin as chiral selector in CE

Rongji Dai; Xiaoying Nie; Hong Li; M. Khalid Saeed; Yulin Deng; Guowei Yao

doi:10.1002/elps.200600651

Investigation of β-CD-derivatized erythromycin as chiral selector in CE

Rongji Dai^*, Xiaoying Nie, Hong Li, M. Khalid Saeed, Yulin Deng, Guowei Yao

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A novel water-soluble β-CD-derivatized erythromycin (EM) was synthesized and used as and effective chiral selector for the resolution of chiral compounds in CZE. The purpose of substitution at the primary hydroxyl site of β-CD with 1-oxygen-2,3-epoxypropane is to produce a compound having functions of both β-CD and EM. β-CD-derivatized EM exhibited excellent enantioselectivities compared with single β-CD and EM for chiral separation in CE. We also investigated the influence of pH and concentration of BGE, concentration of chiral selector, applied potential, and organic modifier on chiral compounds' separation.

Original language	English
Pages (from-to)	2566-2572
Number of pages	7
Journal	Electrophoresis
Volume	28
Issue number	15
DOIs	https://doi.org/10.1002/elps.200600651
Publication status	Published - Aug 2007

Keywords

CE
Chiral selector
Chiral separation
Erythromycin
β-CD

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10.1002/elps.200600651

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abstract = "A novel water-soluble β-CD-derivatized erythromycin (EM) was synthesized and used as and effective chiral selector for the resolution of chiral compounds in CZE. The purpose of substitution at the primary hydroxyl site of β-CD with 1-oxygen-2,3-epoxypropane is to produce a compound having functions of both β-CD and EM. β-CD-derivatized EM exhibited excellent enantioselectivities compared with single β-CD and EM for chiral separation in CE. We also investigated the influence of pH and concentration of BGE, concentration of chiral selector, applied potential, and organic modifier on chiral compounds' separation.",

keywords = "CE, Chiral selector, Chiral separation, Erythromycin, β-CD",

author = "Rongji Dai and Xiaoying Nie and Hong Li and Saeed, {M. Khalid} and Yulin Deng and Guowei Yao",

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AU - Dai, Rongji

AU - Nie, Xiaoying

AU - Li, Hong

AU - Saeed, M. Khalid

AU - Deng, Yulin

AU - Yao, Guowei

PY - 2007/8

Y1 - 2007/8

N2 - A novel water-soluble β-CD-derivatized erythromycin (EM) was synthesized and used as and effective chiral selector for the resolution of chiral compounds in CZE. The purpose of substitution at the primary hydroxyl site of β-CD with 1-oxygen-2,3-epoxypropane is to produce a compound having functions of both β-CD and EM. β-CD-derivatized EM exhibited excellent enantioselectivities compared with single β-CD and EM for chiral separation in CE. We also investigated the influence of pH and concentration of BGE, concentration of chiral selector, applied potential, and organic modifier on chiral compounds' separation.

AB - A novel water-soluble β-CD-derivatized erythromycin (EM) was synthesized and used as and effective chiral selector for the resolution of chiral compounds in CZE. The purpose of substitution at the primary hydroxyl site of β-CD with 1-oxygen-2,3-epoxypropane is to produce a compound having functions of both β-CD and EM. β-CD-derivatized EM exhibited excellent enantioselectivities compared with single β-CD and EM for chiral separation in CE. We also investigated the influence of pH and concentration of BGE, concentration of chiral selector, applied potential, and organic modifier on chiral compounds' separation.

KW - CE

KW - Chiral selector

KW - Chiral separation

KW - Erythromycin

KW - β-CD

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SP - 2566

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JO - Electrophoresis

JF - Electrophoresis

IS - 15

ER -

Investigation of β-CD-derivatized erythromycin as chiral selector in CE

Abstract

Keywords

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