Abstract
Dysfunction of microvascular function and tissue oxygen metabolism has long been associated with a wide range of human diseases, including cardiovascular disease, neurovascular disease, diabetes, and cancer. Capitalizing on the light absorption of blood hemoglobin, photoacoustic microscopy (PAM) has emerged as a promising new technology for high-resolution, label-free, functional-metabolic imaging of the microvasculature in live animals and humans. In this chapter, we introduce multiple different PAM approaches and detailed methodologies for microvascular imaging in both the superficial skin and internal organs. We also review current and potential biomedical applications. Besides, the frontiers of intravital PAM imaging of microvascular function and oxygen metabolism are discussed.
| Original language | English |
|---|---|
| Title of host publication | The Vasculome |
| Subtitle of host publication | From Many, One |
| Publisher | Elsevier |
| Pages | 151-161 |
| Number of pages | 11 |
| ISBN (Electronic) | 9780128225462 |
| ISBN (Print) | 9780128225479 |
| DOIs | |
| Publication status | Published - 1 Jan 2022 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Hemodynamics
- Intravital imaging
- Microvasculature
- Oxygen metabolism
- Photoacoustic microscopy
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