Intravital photoacoustic microscopy of microvascular function and oxygen metabolism

Naidi Sun; Song Hu

doi:10.1016/B978-0-12-822546-2.00002-2

Intravital photoacoustic microscopy of microvascular function and oxygen metabolism

Naidi Sun, Song Hu

Washington University St. Louis

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Dysfunction of microvascular function and tissue oxygen metabolism has long been associated with a wide range of human diseases, including cardiovascular disease, neurovascular disease, diabetes, and cancer. Capitalizing on the light absorption of blood hemoglobin, photoacoustic microscopy (PAM) has emerged as a promising new technology for high-resolution, label-free, functional-metabolic imaging of the microvasculature in live animals and humans. In this chapter, we introduce multiple different PAM approaches and detailed methodologies for microvascular imaging in both the superficial skin and internal organs. We also review current and potential biomedical applications. Besides, the frontiers of intravital PAM imaging of microvascular function and oxygen metabolism are discussed.

Original language	English
Title of host publication	The Vasculome
Subtitle of host publication	From Many, One
Publisher	Elsevier
Pages	151-161
Number of pages	11
ISBN (Electronic)	9780128225462
ISBN (Print)	9780128225479
DOIs	https://doi.org/10.1016/B978-0-12-822546-2.00002-2
Publication status	Published - 1 Jan 2022
Externally published	Yes

Keywords

Hemodynamics
Intravital imaging
Microvasculature
Oxygen metabolism
Photoacoustic microscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-822546-2.00002-2

Cite this

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title = "Intravital photoacoustic microscopy of microvascular function and oxygen metabolism",

abstract = "Dysfunction of microvascular function and tissue oxygen metabolism has long been associated with a wide range of human diseases, including cardiovascular disease, neurovascular disease, diabetes, and cancer. Capitalizing on the light absorption of blood hemoglobin, photoacoustic microscopy (PAM) has emerged as a promising new technology for high-resolution, label-free, functional-metabolic imaging of the microvasculature in live animals and humans. In this chapter, we introduce multiple different PAM approaches and detailed methodologies for microvascular imaging in both the superficial skin and internal organs. We also review current and potential biomedical applications. Besides, the frontiers of intravital PAM imaging of microvascular function and oxygen metabolism are discussed.",

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AU - Hu, Song

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N2 - Dysfunction of microvascular function and tissue oxygen metabolism has long been associated with a wide range of human diseases, including cardiovascular disease, neurovascular disease, diabetes, and cancer. Capitalizing on the light absorption of blood hemoglobin, photoacoustic microscopy (PAM) has emerged as a promising new technology for high-resolution, label-free, functional-metabolic imaging of the microvasculature in live animals and humans. In this chapter, we introduce multiple different PAM approaches and detailed methodologies for microvascular imaging in both the superficial skin and internal organs. We also review current and potential biomedical applications. Besides, the frontiers of intravital PAM imaging of microvascular function and oxygen metabolism are discussed.

AB - Dysfunction of microvascular function and tissue oxygen metabolism has long been associated with a wide range of human diseases, including cardiovascular disease, neurovascular disease, diabetes, and cancer. Capitalizing on the light absorption of blood hemoglobin, photoacoustic microscopy (PAM) has emerged as a promising new technology for high-resolution, label-free, functional-metabolic imaging of the microvasculature in live animals and humans. In this chapter, we introduce multiple different PAM approaches and detailed methodologies for microvascular imaging in both the superficial skin and internal organs. We also review current and potential biomedical applications. Besides, the frontiers of intravital PAM imaging of microvascular function and oxygen metabolism are discussed.

KW - Hemodynamics

KW - Intravital imaging

KW - Microvasculature

KW - Oxygen metabolism

KW - Photoacoustic microscopy

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U2 - 10.1016/B978-0-12-822546-2.00002-2

DO - 10.1016/B978-0-12-822546-2.00002-2

M3 - Chapter

AN - SCOPUS:85137585453

SN - 9780128225479

SP - 151

EP - 161

BT - The Vasculome

PB - Elsevier

ER -

Intravital photoacoustic microscopy of microvascular function and oxygen metabolism

Abstract

Keywords

UN SDGs

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