Integration of a novel attribute and classical topology metrics of hyper-networks for automatic diagnosis of Major depressive disorder

Conventional hyper-network coefficients ignore the weighted hyper-edge information which could be vital in researching the specificity of brain disease. Functional hyper-networks for 64 healthy controls (HC) and 56 patients with major depressive disorder (MDD) were constructed using the least absolute shrinkage and selection operator (Lasso). Not only the classical topology metrics but also a novel hyper-edge weight (HEW) attribute were extracted as features to promote the functional-based auto-diagnosis accuracy of MDD. We compared the categorization performance of each hyper-network coefficient. A multi-feature ensemble model was applied to fuse different kinds of features. We obtained 82.15 % accuracy with the classical hyper-network clustering coefficient (HCC) and 84.08 % accuracy with the HEW attribute on the MDD dataset. The performance was further improved to 89.24% by combining all the properties of the hyper-networks. The multi-feature ensemble model combining different hyper-network coefficients provides new insights into the automatic diagnosis with diverse information of MDD.