Influence of laser power density on damage of comb by photodynamic therapy - Simulation and validation of mathematical models

Naiyan Huang; Zhongshun Ma; Ying Wang; Jing Zeng; Haixia Qiu; Xiaoying Tang; Ying Gu

doi:10.3788/COL201412.031701

Influence of laser power density on damage of comb by photodynamic therapy - Simulation and validation of mathematical models

Naiyan Huang, Zhongshun Ma, Ying Wang, Jing Zeng, Haixia Qiu, Xiaoying Tang, Ying Gu^*

^*Corresponding author for this work

School of Medical and Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Photodynamic therapy (PDT) has poor therapeutic outcomes for the treatment of port-wine stain (PWS) lesions with long drug-light intervals (DLIs). This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations (¹O₂). Both simulation and experimental results show that increasing the power density from 100 to 140 mW/cm² not only improves the PDT efficacy, but also results in the unwanted skin damage.

Original language	English
Article number	031701
Journal	Chinese Optics Letters
Volume	12
Issue number	3
DOIs	https://doi.org/10.3788/COL201412.031701
Publication status	Published - Mar 2014

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abstract = "Photodynamic therapy (PDT) has poor therapeutic outcomes for the treatment of port-wine stain (PWS) lesions with long drug-light intervals (DLIs). This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations (1O2). Both simulation and experimental results show that increasing the power density from 100 to 140 mW/cm2 not only improves the PDT efficacy, but also results in the unwanted skin damage.",

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AU - Huang, Naiyan

AU - Ma, Zhongshun

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AU - Zeng, Jing

AU - Qiu, Haixia

AU - Tang, Xiaoying

AU - Gu, Ying

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AB - Photodynamic therapy (PDT) has poor therapeutic outcomes for the treatment of port-wine stain (PWS) lesions with long drug-light intervals (DLIs). This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations (1O2). Both simulation and experimental results show that increasing the power density from 100 to 140 mW/cm2 not only improves the PDT efficacy, but also results in the unwanted skin damage.

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Influence of laser power density on damage of comb by photodynamic therapy - Simulation and validation of mathematical models

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