Abstract
Imaging-guided stimuli-responsive drug delivery systems have emerged as a functional platform in cancer theranostics. The encapsulation of various functional nanoparticles into one nanocarrier has been evaluated over the past 10 years to develop effective drug delivery and cell/tissue imaging for cancer diagnosis and therapy. Among them, the combination of photothermal therapy (PTT), chemotherapy, and diagnostic imaging is the most popular way due to their bright, foreseeable future. The novel nanomedicine platform is a promising method to enhance therapeutic efficiency and reduce the side effects. In this chapter, PTT and the corresponding nanomaterials are introduced. The conventional and novel imaging technologies are then reviewed, including the characteristics of nanomaterials as contrast agents. The imaging-guided PTT and chemotherapy are summarized, focusing on three typical materials, gold nanoparticles, carbon nanomaterials and polymeric nanomaterials. In conclusion, imaging-guided synergistic photothermal and chemotherapy, which is becoming one of the mainstream solution for cancer theranostics in the future, is reviewed. It will certainly help us to enter a new stage of personalized cancer treatment.
| Original language | English |
|---|---|
| Title of host publication | Nanomaterials for Drug Delivery and Therapy |
| Publisher | Elsevier |
| Pages | 117-147 |
| Number of pages | 31 |
| ISBN (Electronic) | 9780128165058 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
| Externally published | Yes |
Keywords
- Cancer diagnosis
- Cancer therapy
- Chemotherapy
- Multimodal imaging
- Photothermal therapy
- Theranostics