Host-Guest Strategy for Organic Phosphorescence to Generate Oxygen Radical over Singlet Oxygen

Lingling Kang, Cong Chao, Chenchen Xiong, Shuang Yu, Changtao Xiao, Changsheng Zhao, Shisheng Cui, Jiguang Li, Jing Li, Jianbing Shi, Bin Tong, Zhuo Wang, Yin Song*, Weiqian Zhao, Zhengxu Cai*, Yuping Dong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Exciton dynamics exert a pivotal role in the photodynamic efficiency of photosensitizers, however, strategies for modulating exciton dynamics to motivate electron transfer in exciton-involved photoreactions remain largely unexplored. Herein, we employed a cutting-edge microfluidic platform combined with computational fluid dynamics to encapsulate a commercial type II PS [rose Bengal (RB)] within a rigid host matrix. This encapsulation yielded host/RB nanoparticles (NPs) with a uniform structure and controllable size. The photoexcited dynamics of these host/RB NPs were characterized using time-resolved spectroscopy, and the results revealed that encapsulation not only extended the triplet exciton lifetime of RB, but also created an optimized environment to motivate electron transfer between RB molecules. These findings rationalize the observed remarkable 20-fold reduction in type II photoreaction and a 3-fold promotion in type I photoreaction for host/RB NPs. Due to the dramatic generation of HO and O2•-, host/RB NPs demonstrated excellent ability for the in vitro eradication of Staphylococcus aureus and Escherichia coli biofilms and the in vivo treatment of S. aureus-infected wounds under hypoxia, with a minimum killing concentration of 10-7 M. This work sheds light on the motivation of exciton transfer to develop type I PS with enhanced photodynamic properties.

Original languageEnglish
Pages (from-to)7332-7342
Number of pages11
JournalChemistry of Materials
Volume36
Issue number15
DOIs
Publication statusPublished - 13 Aug 2024

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