Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts

Juan Dong; Da Ming Du

doi:10.1039/c2ob26334c

Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts

Juan Dong
, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).

Original language	English
Pages (from-to)	8125-8131
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	40
DOIs	https://doi.org/10.1039/c2ob26334c
Publication status	Published - 28 Oct 2012

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title = "Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts",

abstract = "An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99\%) and good to excellent enantioselectivities (up to 99\% ee).",

author = "Juan Dong and Du, \{Da Ming\}",

year = "2012",

month = oct,

day = "28",

doi = "10.1039/c2ob26334c",

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pages = "8125--8131",

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T1 - Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts

AU - Dong, Juan

AU - Du, Da Ming

PY - 2012/10/28

Y1 - 2012/10/28

N2 - An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).

AB - An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).

UR - https://www.scopus.com/pages/publications/84866952714

U2 - 10.1039/c2ob26334c

DO - 10.1039/c2ob26334c

M3 - Article

C2 - 22956019

AN - SCOPUS:84866952714

SN - 1477-0520

VL - 10

SP - 8125

EP - 8131

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 40

ER -

Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts

Abstract

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