Abstract
An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).
Original language | English |
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Pages (from-to) | 8125-8131 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 10 |
Issue number | 40 |
DOIs | |
Publication status | Published - 28 Oct 2012 |