Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts

Juan Dong, Da Ming Du*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).

Original languageEnglish
Pages (from-to)8125-8131
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number40
DOIs
Publication statusPublished - 28 Oct 2012

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