Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry

Rui Su; Yahui Liu; Yun Wang; Yongqian Zhang; Qing Hong; Yulin Deng

doi:10.1109/ICCME.2013.6548298

Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry

Rui Su
, Yahui Liu
, Yun Wang
, Yongqian Zhang
, Qing Hong
, Yulin Deng^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.

Original language	English
Title of host publication	2013 ICME International Conference on Complex Medical Engineering, CME 2013
Pages	493-496
Number of pages	4
DOIs	https://doi.org/10.1109/ICCME.2013.6548298
Publication status	Published - 2013
Event	2013 7th ICME International Conference on Complex Medical Engineering, CME 2013 - Beijing, China Duration: 25 May 2013 → 28 May 2013

Publication series

Name	2013 ICME International Conference on Complex Medical Engineering, CME 2013

Conference

Conference	2013 7th ICME International Conference on Complex Medical Engineering, CME 2013
Country/Territory	China
City	Beijing
Period	25/05/13 → 28/05/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CID
Fragmentation
Non-enzymatic glycation
neutral loss

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10.1109/ICCME.2013.6548298

Cite this

Su, R., Liu, Y., Wang, Y., Zhang, Y., Hong, Q., & Deng, Y. (2013). Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry. In 2013 ICME International Conference on Complex Medical Engineering, CME 2013 (pp. 493-496). Article 6548298 (2013 ICME International Conference on Complex Medical Engineering, CME 2013). https://doi.org/10.1109/ICCME.2013.6548298

@inproceedings{a1dcc84502a2428eacd904691958545b,

title = "Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry",

abstract = "Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.",

keywords = "CID, Fragmentation, Non-enzymatic glycation, neutral loss",

author = "Rui Su and Yahui Liu and Yun Wang and Yongqian Zhang and Qing Hong and Yulin Deng",

year = "2013",

doi = "10.1109/ICCME.2013.6548298",

language = "English",

isbn = "9781467329699",

series = "2013 ICME International Conference on Complex Medical Engineering, CME 2013",

pages = "493--496",

booktitle = "2013 ICME International Conference on Complex Medical Engineering, CME 2013",

note = "2013 7th ICME International Conference on Complex Medical Engineering, CME 2013 ; Conference date: 25-05-2013 Through 28-05-2013",

}

Su, R, Liu, Y, Wang, Y , Zhang, Y, Hong, Q & Deng, Y 2013, Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry. in 2013 ICME International Conference on Complex Medical Engineering, CME 2013., 6548298, 2013 ICME International Conference on Complex Medical Engineering, CME 2013, pp. 493-496, 2013 7th ICME International Conference on Complex Medical Engineering, CME 2013, Beijing, China, 25/05/13. https://doi.org/10.1109/ICCME.2013.6548298

Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry. / Su, Rui; Liu, Yahui; Wang, Yun et al.
2013 ICME International Conference on Complex Medical Engineering, CME 2013. 2013. p. 493-496 6548298 (2013 ICME International Conference on Complex Medical Engineering, CME 2013).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry

AU - Su, Rui

AU - Liu, Yahui

AU - Wang, Yun

AU - Zhang, Yongqian

AU - Hong, Qing

AU - Deng, Yulin

PY - 2013

Y1 - 2013

N2 - Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.

AB - Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.

KW - CID

KW - Fragmentation

KW - Non-enzymatic glycation

KW - neutral loss

UR - https://www.scopus.com/pages/publications/84881501559

U2 - 10.1109/ICCME.2013.6548298

DO - 10.1109/ICCME.2013.6548298

M3 - Conference contribution

AN - SCOPUS:84881501559

SN - 9781467329699

T3 - 2013 ICME International Conference on Complex Medical Engineering, CME 2013

SP - 493

EP - 496

BT - 2013 ICME International Conference on Complex Medical Engineering, CME 2013

T2 - 2013 7th ICME International Conference on Complex Medical Engineering, CME 2013

Y2 - 25 May 2013 through 28 May 2013

ER -

Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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