Abstract
Parkinson's disease (PD) is progressive neurodegenerative disorder and the exactly mechanism is still unknown. The extregenous and endogenous neurotoxin provoked by environmental factors may contribute to the development of PD and drew more and more attention. Based on our research data, a hypothesis of PD pathogenesis that CAIQs and related enzymes were involved in the dopaminergic neurons death had been proposed. In order to verify this hypothesis, the 6-OHDA lesion rat model was established and a method based on HPLC- ESI-TOF was developed for the determination of Sal and NMSal in nigra-striatum. Data showed that the Sal and NMSal in damaged regions of PD significantly raised (P < 0.05) compared to the control group, which firmly support the suggested hypothesis.
| Original language | English |
|---|---|
| Pages (from-to) | 439-442 |
| Number of pages | 4 |
| Journal | Chemistry Bulletin / Huaxue Tongbao |
| Volume | 71 |
| Issue number | 6 |
| Publication status | Published - 2008 |
Keywords
- Catecholamine isoquinolines
- Endogenous neurotoxin
- Parkinson Disease