TY - GEN
T1 - Flexible Wearable Sensor Based on Molecularly Imprinted Polymers for Wound Glucose Monitoring
AU - Gong, Jiale
AU - Wang, Xuan
AU - Ma, Yizhuo
AU - Abbasi, Maria
AU - Lei, Runhong
AU - Ma, Shengnan
AU - Mounir, Herhira Taha Siredj
AU - Zhang, Niu
AU - Zhang, Long
AU - Wei, Jing
AU - Geng, Lina
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2026.
PY - 2026
Y1 - 2026
N2 - In clinical management of diabetic foot ulcers, dynamic monitoring of wound glucose is critical for infection risk assessment and treatment guidance. However, molecular detection in exudate remains challenging due to sample complexity and low analyte concentrations. Electrochemical sensors provide an ideal platform owing to their high sensitivity and miniaturization potential. Notably, molecularly imprinted polymers (MIPs) have gained attention as synthetic receptors with customizable binding sites, excellent stability, and low-cost mass production. Despite growing interest in MIP-based wearable sensors, their application in wound monitoring—including for glucose—has not been explored. To address this gap, we developed a flexible electrochemical sensor using a glucose-selective MIP film. This device overcomes key limitations of traditional biological receptors in wound environments. The optimized sensor shows a wide linear range (0.1 μM-1 mM, R2 > 0.97) and accurate glucose detection in wound exudate. Our work provides a scalable, low-cost sensing platform that enables intelligent wound management systems to transition from passive observation to active, offering a novel approach for diabetic wound monitoring.
AB - In clinical management of diabetic foot ulcers, dynamic monitoring of wound glucose is critical for infection risk assessment and treatment guidance. However, molecular detection in exudate remains challenging due to sample complexity and low analyte concentrations. Electrochemical sensors provide an ideal platform owing to their high sensitivity and miniaturization potential. Notably, molecularly imprinted polymers (MIPs) have gained attention as synthetic receptors with customizable binding sites, excellent stability, and low-cost mass production. Despite growing interest in MIP-based wearable sensors, their application in wound monitoring—including for glucose—has not been explored. To address this gap, we developed a flexible electrochemical sensor using a glucose-selective MIP film. This device overcomes key limitations of traditional biological receptors in wound environments. The optimized sensor shows a wide linear range (0.1 μM-1 mM, R2 > 0.97) and accurate glucose detection in wound exudate. Our work provides a scalable, low-cost sensing platform that enables intelligent wound management systems to transition from passive observation to active, offering a novel approach for diabetic wound monitoring.
KW - Diabetic wound
KW - Electrochemical biosensor
KW - Flexible wearable sensor
KW - Glucose monitoring
KW - Molecularly imprinted polymer
UR - https://www.scopus.com/pages/publications/105045570601
U2 - 10.1007/978-981-95-6739-3_4
DO - 10.1007/978-981-95-6739-3_4
M3 - Conference contribution
AN - SCOPUS:105045570601
SN - 9789819567386
T3 - Communications in Computer and Information Science
SP - 50
EP - 61
BT - Advanced Computational Intelligence and Intelligent Informatics - 9th International Workshop, IWACIII 2025, Proceedings
A2 - Ma, Hongbin
A2 - Xin, Bin
A2 - She, Jinhua
A2 - Lu, Guiping
PB - Springer Science and Business Media Deutschland GmbH
T2 - 9th International Workshop on Advanced Computational Intelligence and Intelligent Informatics, IWACIII 2025
Y2 - 31 October 2025 through 4 November 2025
ER -