Facile synthesis of chiral 2-amino-4-(indol-3-yl)-4H-chromene derivatives using thiourea as the catalyst

Yu Gao; Da Ming Du

doi:10.1016/j.tetasy.2013.08.018

Facile synthesis of chiral 2-amino-4-(indol-3-yl)-4H-chromene derivatives using thiourea as the catalyst

Yu Gao
, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The enantioselective Friedel-Crafts alkylation of indoles with iminochromenes catalyzed by a bifunctional thiourea organocatalyst was investigated. This reaction afforded chiral functionalized 2-amino-4-(indol-3- yl)-4H-chromenes in good yields (up to 87% yield) and with moderate to good enantioselectivities (up to 86% ee).

Original language	English
Pages (from-to)	1312-1317
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	24
Issue number	20
DOIs	https://doi.org/10.1016/j.tetasy.2013.08.018
Publication status	Published - 31 Oct 2013

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title = "Facile synthesis of chiral 2-amino-4-(indol-3-yl)-4H-chromene derivatives using thiourea as the catalyst",

abstract = "The enantioselective Friedel-Crafts alkylation of indoles with iminochromenes catalyzed by a bifunctional thiourea organocatalyst was investigated. This reaction afforded chiral functionalized 2-amino-4-(indol-3- yl)-4H-chromenes in good yields (up to 87\% yield) and with moderate to good enantioselectivities (up to 86\% ee).",

author = "Yu Gao and Du, \{Da Ming\}",

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AU - Gao, Yu

AU - Du, Da Ming

PY - 2013/10/31

Y1 - 2013/10/31

N2 - The enantioselective Friedel-Crafts alkylation of indoles with iminochromenes catalyzed by a bifunctional thiourea organocatalyst was investigated. This reaction afforded chiral functionalized 2-amino-4-(indol-3- yl)-4H-chromenes in good yields (up to 87% yield) and with moderate to good enantioselectivities (up to 86% ee).

AB - The enantioselective Friedel-Crafts alkylation of indoles with iminochromenes catalyzed by a bifunctional thiourea organocatalyst was investigated. This reaction afforded chiral functionalized 2-amino-4-(indol-3- yl)-4H-chromenes in good yields (up to 87% yield) and with moderate to good enantioselectivities (up to 86% ee).

UR - https://www.scopus.com/pages/publications/84886952060

U2 - 10.1016/j.tetasy.2013.08.018

DO - 10.1016/j.tetasy.2013.08.018

M3 - Article

AN - SCOPUS:84886952060

SN - 0957-4166

VL - 24

SP - 1312

EP - 1317

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 20

ER -

Facile synthesis of chiral 2-amino-4-(indol-3-yl)-4H-chromene derivatives using thiourea as the catalyst

Abstract

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