Facile synthesis of 1,1-disubstituted taurines

Jiaxing Huang; Da Ming Du; Jiaxi Xu

doi:10.1016/j.ygeno.2005.11.011

Facile synthesis of 1,1-disubstituted taurines

Jiaxing Huang, Da Ming Du, Jiaxi Xu^*

^*Corresponding author for this work

Peking University

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

A series of 1,1 -disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid.

Original language	English
Article number	F10605SS
Pages (from-to)	315-319
Number of pages	5
Journal	Synthesis
Issue number	2
DOIs	https://doi.org/10.1016/j.ygeno.2005.11.011
Publication status	Published - 18 Jan 2006
Externally published	Yes

Keywords

Amino acid
Aminoalkanesulfonic acid
Episulfide
Epoxide
Ketone
Synthesis
Taurine

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10.1016/j.ygeno.2005.11.011

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abstract = "A series of 1,1 -disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid.",

keywords = "Amino acid, Aminoalkanesulfonic acid, Episulfide, Epoxide, Ketone, Synthesis, Taurine",

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AU - Huang, Jiaxing

AU - Du, Da Ming

AU - Xu, Jiaxi

PY - 2006/1/18

Y1 - 2006/1/18

N2 - A series of 1,1 -disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid.

AB - A series of 1,1 -disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid.

KW - Amino acid

KW - Aminoalkanesulfonic acid

KW - Episulfide

KW - Epoxide

KW - Ketone

KW - Synthesis

KW - Taurine

UR - https://www.scopus.com/pages/publications/31544456638

U2 - 10.1016/j.ygeno.2005.11.011

DO - 10.1016/j.ygeno.2005.11.011

M3 - Article

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SP - 315

EP - 319

JO - Synthesis

JF - Synthesis

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M1 - F10605SS

ER -

Facile synthesis of 1,1-disubstituted taurines

Abstract

Keywords

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