Fabrication of multilayered hepatic lobule tissues using Ca-alginate hydrogel platforms

Zeyang Liu, Minmin Lu, Masahiro Nakajima, Masaru Takeuchi, Yasuhisa Hasegawa, Toshio Fukuda, Qiang Huang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Artificial cell sheet is utilized as a useful method for tissue engineering. We proposed a novel approach to fabricate the Ca-alginate gel sheet embedded liver cells to mimic the liver lobule tissue. Ca-alginate sheet with hepatic lobule shaped pattern was firstly deposited on a micro-electrode device based on the electrodeposition method. Viability of embedded cells was checked to be maintained more than 90%. What's more, we further stacked the fabricated cell sheets into a pre-designed PDMS mold. The stacked multi-layered 3D cell structure can contribute the possibility for the applications of artificial liver fabrication.

Original languageEnglish
Title of host publication2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages561-564
Number of pages4
ISBN (Electronic)9781509030286
DOIs
Publication statusPublished - 21 Nov 2017
Event17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
Duration: 25 Jul 201728 Jul 2017

Publication series

Name2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

Conference

Conference17th IEEE International Conference on Nanotechnology, NANO 2017
Country/TerritoryUnited States
CityPittsburgh
Period25/07/1728/07/17

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