TY - JOUR
T1 - Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer
AU - Li, Yanping
AU - Wang, Shanshan
AU - Zhang, Xiaoyuan
AU - Yang, Rui
AU - Wei, Xiaonan
AU - Yan, Ruirong
AU - Jiang, Yaru
AU - Shen, Wenzhi
N1 - Publisher Copyright:
© Copyright © 2021 Li, Wang, Zhang, Yang, Wei, Yan, Jiang and Shen.
PY - 2021/7/5
Y1 - 2021/7/5
N2 - It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox regression analysis showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer.
AB - It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox regression analysis showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer.
KW - breast cancer
KW - comprehensive analysis 3
KW - PGK1
KW - prognostic
KW - prognostic value
KW - public databases
UR - http://www.scopus.com/inward/record.url?scp=85110851591&partnerID=8YFLogxK
U2 - 10.3389/fmolb.2021.695420
DO - 10.3389/fmolb.2021.695420
M3 - Article
AN - SCOPUS:85110851591
SN - 2296-889X
VL - 8
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
M1 - 695420
ER -