Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss

Xinyu Shi; Xianbao Cao; Renjie Chai; Suijun Chen; Juan Feng; Ningyu Feng; Xia Gao; Lulu Guo; Yuhe Liu; Ling Lu; Lingyun Mei; Xiaoyun Qian; Dongdong Ren; Haibo Shi; Duoduo Tao; Qin Wang; Zhaoyan Wang; Shuo Wang; Wei Wang; Ming Xia; Hao Xiong; Baicheng Xu; Kai Xu; Lei Xu; Hua Yang; Jun Yang; Pingli Yang; Wei Yuan; Dingjun Zha; Chunming Zhang; Hongzheng Zhang; Juan Zhang; Tianhong Zhang; Wenqi Zuo; Wenyan Li; Yongyi Yuan; Jie Zhang; Yu Zhao; Fang Zheng; Yu Sun

doi:10.13201/j.issn.2096-7993.2025.09.002

Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss

Xinyu Shi
, Xianbao Cao
, Renjie Chai
, Suijun Chen
, Juan Feng
, Ningyu Feng
, Xia Gao
, Lulu Guo
, Yuhe Liu
, Ling Lu
, Lingyun Mei
, Xiaoyun Qian
, Dongdong Ren
, Haibo Shi
, Duoduo Tao
, Qin Wang
, Zhaoyan Wang
, Shuo Wang
, Wei Wang
, Ming Xia

Hao Xiong, Baicheng Xu, Kai Xu, Lei Xu, Hua Yang, Jun Yang, Pingli Yang, Wei Yuan, Dingjun Zha, Chunming Zhang, Hongzheng Zhang, Juan Zhang, Tianhong Zhang, Wenqi Zuo, Wenyan Li, Yongyi Yuan, Jie Zhang, Yu Zhao, Fang Zheng, Yu Sun

School of Life Science

Research output: Contribution to journal › Article › peer-review

Abstract

摘要: 听力损失是最常见的致残性疾病，人工耳蜗植入（cochlear implantation，CI）是治疗重度至极重度听力损失的主要手段。本共识通过德尔非法系统探讨了基因诊断在CI术前评估及疗效预后中的价值和意义，参考国内外研究及临床经验，提出了基于循证医学的三级预后分级体系（良好、临界、不良）。本共识聚焦于与先天性听力损失密切相关的常见遗传性非综合征型听力损失（如GJB2、SLC26A4、OTOF、LOXHD1等基因突变致病）及遗传性综合征型听力损失（如Jervell & Lange-Nielsen综合征、Waardenburg综合征等），分析其病理机制对CI效果的影响。共识通过多轮专家研讨及投票形成推荐意见，强调基因诊断可优化患者选择、预测预后并指导术后康复，为不同基因型患者提供分层管理策略，推动精准医疗在CI领域的应用。.

Original language	English
Pages (from-to)	798-808
Number of pages	11
Journal	Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Volume	39
Issue number	9
DOIs	https://doi.org/10.13201/j.issn.2096-7993.2025.09.002
Publication status	Published - 1 Sept 2025

Keywords

cochlear implantation
genetic diagnosis
hereditary hearing loss

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10.13201/j.issn.2096-7993.2025.09.002

Cite this

Shi, X., Cao, X., Chai, R., Chen, S., Feng, J., Feng, N., Gao, X., Guo, L., Liu, Y., Lu, L., Mei, L., Qian, X., Ren, D., Shi, H., Tao, D., Wang, Q., Wang, Z., Wang, S., Wang, W., ... Sun, Y. (2025). Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 39(9), 798-808. https://doi.org/10.13201/j.issn.2096-7993.2025.09.002

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title = "Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss",

abstract = "摘要: 听力损失是最常见的致残性疾病，人工耳蜗植入（cochlear implantation，CI）是治疗重度至极重度听力损失的主要手段。本共识通过德尔非法系统探讨了基因诊断在CI术前评估及疗效预后中的价值和意义，参考国内外研究及临床经验，提出了基于循证医学的三级预后分级体系（良好、临界、不良）。本共识聚焦于与先天性听力损失密切相关的常见遗传性非综合征型听力损失（如GJB2、SLC26A4、OTOF、LOXHD1等基因突变致病）及遗传性综合征型听力损失（如Jervell \& Lange-Nielsen综合征、Waardenburg综合征等），分析其病理机制对CI效果的影响。共识通过多轮专家研讨及投票形成推荐意见，强调基因诊断可优化患者选择、预测预后并指导术后康复，为不同基因型患者提供分层管理策略，推动精准医疗在CI领域的应用。.",

keywords = "cochlear implantation, genetic diagnosis, hereditary hearing loss",

author = "Xinyu Shi and Xianbao Cao and Renjie Chai and Suijun Chen and Juan Feng and Ningyu Feng and Xia Gao and Lulu Guo and Yuhe Liu and Ling Lu and Lingyun Mei and Xiaoyun Qian and Dongdong Ren and Haibo Shi and Duoduo Tao and Qin Wang and Zhaoyan Wang and Shuo Wang and Wei Wang and Ming Xia and Hao Xiong and Baicheng Xu and Kai Xu and Lei Xu and Hua Yang and Jun Yang and Pingli Yang and Wei Yuan and Dingjun Zha and Chunming Zhang and Hongzheng Zhang and Juan Zhang and Tianhong Zhang and Wenqi Zuo and Wenyan Li and Yongyi Yuan and Jie Zhang and Yu Zhao and Fang Zheng and Yu Sun",

year = "2025",

month = sep,

day = "1",

doi = "10.13201/j.issn.2096-7993.2025.09.002",

language = "English",

volume = "39",

pages = "798--808",

journal = "Journal of Clinical Otorhinolaryngology Head and Neck Surgery",

issn = "2096-7993",

publisher = "Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery",

number = "9",

}

Shi, X, Cao, X, Chai, R, Chen, S, Feng, J, Feng, N, Gao, X, Guo, L, Liu, Y, Lu, L, Mei, L, Qian, X, Ren, D, Shi, H, Tao, D, Wang, Q, Wang, Z, Wang, S, Wang, W, Xia, M, Xiong, H, Xu, B, Xu, K, Xu, L, Yang, H, Yang, J, Yang, P, Yuan, W, Zha, D, Zhang, C, Zhang, H, Zhang, J, Zhang, T, Zuo, W, Li, W, Yuan, Y, Zhang, J, Zhao, Y, Zheng, F & Sun, Y 2025, 'Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss', Journal of Clinical Otorhinolaryngology Head and Neck Surgery, vol. 39, no. 9, pp. 798-808. https://doi.org/10.13201/j.issn.2096-7993.2025.09.002

TY - JOUR

T1 - Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss

AU - Shi, Xinyu

AU - Cao, Xianbao

AU - Chai, Renjie

AU - Chen, Suijun

AU - Feng, Juan

AU - Feng, Ningyu

AU - Gao, Xia

AU - Guo, Lulu

AU - Liu, Yuhe

AU - Lu, Ling

AU - Mei, Lingyun

AU - Qian, Xiaoyun

AU - Ren, Dongdong

AU - Shi, Haibo

AU - Tao, Duoduo

AU - Wang, Qin

AU - Wang, Zhaoyan

AU - Wang, Shuo

AU - Wang, Wei

AU - Xia, Ming

AU - Xiong, Hao

AU - Xu, Baicheng

AU - Xu, Kai

AU - Xu, Lei

AU - Yang, Hua

AU - Yang, Jun

AU - Yang, Pingli

AU - Yuan, Wei

AU - Zha, Dingjun

AU - Zhang, Chunming

AU - Zhang, Hongzheng

AU - Zhang, Juan

AU - Zhang, Tianhong

AU - Zuo, Wenqi

AU - Li, Wenyan

AU - Yuan, Yongyi

AU - Zhang, Jie

AU - Zhao, Yu

AU - Zheng, Fang

AU - Sun, Yu

PY - 2025/9/1

Y1 - 2025/9/1

N2 - 摘要: 听力损失是最常见的致残性疾病，人工耳蜗植入（cochlear implantation，CI）是治疗重度至极重度听力损失的主要手段。本共识通过德尔非法系统探讨了基因诊断在CI术前评估及疗效预后中的价值和意义，参考国内外研究及临床经验，提出了基于循证医学的三级预后分级体系（良好、临界、不良）。本共识聚焦于与先天性听力损失密切相关的常见遗传性非综合征型听力损失（如GJB2、SLC26A4、OTOF、LOXHD1等基因突变致病）及遗传性综合征型听力损失（如Jervell & Lange-Nielsen综合征、Waardenburg综合征等），分析其病理机制对CI效果的影响。共识通过多轮专家研讨及投票形成推荐意见，强调基因诊断可优化患者选择、预测预后并指导术后康复，为不同基因型患者提供分层管理策略，推动精准医疗在CI领域的应用。.

AB - 摘要: 听力损失是最常见的致残性疾病，人工耳蜗植入（cochlear implantation，CI）是治疗重度至极重度听力损失的主要手段。本共识通过德尔非法系统探讨了基因诊断在CI术前评估及疗效预后中的价值和意义，参考国内外研究及临床经验，提出了基于循证医学的三级预后分级体系（良好、临界、不良）。本共识聚焦于与先天性听力损失密切相关的常见遗传性非综合征型听力损失（如GJB2、SLC26A4、OTOF、LOXHD1等基因突变致病）及遗传性综合征型听力损失（如Jervell & Lange-Nielsen综合征、Waardenburg综合征等），分析其病理机制对CI效果的影响。共识通过多轮专家研讨及投票形成推荐意见，强调基因诊断可优化患者选择、预测预后并指导术后康复，为不同基因型患者提供分层管理策略，推动精准医疗在CI领域的应用。.

KW - cochlear implantation

KW - genetic diagnosis

KW - hereditary hearing loss

UR - https://www.scopus.com/pages/publications/105015669108

U2 - 10.13201/j.issn.2096-7993.2025.09.002

DO - 10.13201/j.issn.2096-7993.2025.09.002

M3 - Article

C2 - 40898891

AN - SCOPUS:105015669108

SN - 2096-7993

VL - 39

SP - 798

EP - 808

JO - Journal of Clinical Otorhinolaryngology Head and Neck Surgery

JF - Journal of Clinical Otorhinolaryngology Head and Neck Surgery

IS - 9

ER -

Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss

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Keywords

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