Experimental demonstration and optimization of X-ray StaticCodeCT

As the use of X-ray computed tomography (CT) grows in medical diagnosis, so does the concern for the harm a radiation dose can cause and the biological risks it represents. StaticCodeCT is a new low-dose imaging architecture that uses a single-static coded aperture (CA) in a CT gantry. It exploits the highly correlated data in the projection domain to estimate the unobserved measurements on the detector. We previously analyzed the StaticCodeCT system by emulating the effect of the coded mask on experimental CT data. In contrast, this manuscript presents test-bed reconstructions using an experimental cone-beam X-ray CT system with a CA holder. We analyzed the reconstruction quality using three different techniques to manufacture the CAs: metal additive manufacturing, cold casting, and ceramic additive manufacturing. Furthermore, we propose an optimization method to design the CA pattern based on the algorithm developed for the measurement estimation. The obtained results point to the possibility of the real deployment of StaticCodeCT systems in practice.