Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor

Chun Cui Huang; Hui Bo Shao

doi:10.1016/j.cclet.2011.11.003

Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor

Chun Cui Huang, Hui Bo Shao^*

^*Corresponding author for this work

Ministry of Education in China

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF® solution, a copolymer of tetrafluoroethylene and 2,2-bis(trifluoroethylene)-4, 5-difluoro-1,3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	Chinese Chemical Letters
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.cclet.2011.11.003
Publication status	Published - Feb 2012
Externally published	Yes

Keywords

Enhanced FIA method
Highly selective NO sensor
Plasma
RSNOs

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10.1016/j.cclet.2011.11.003

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title = "Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor",

abstract = "A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF{\textregistered} solution, a copolymer of tetrafluoroethylene and 2,2-bis(trifluoroethylene)-4, 5-difluoro-1,3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.",

keywords = "Enhanced FIA method, Highly selective NO sensor, Plasma, RSNOs",

author = "Huang, {Chun Cui} and Shao, {Hui Bo}",

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AU - Huang, Chun Cui

AU - Shao, Hui Bo

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N2 - A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF® solution, a copolymer of tetrafluoroethylene and 2,2-bis(trifluoroethylene)-4, 5-difluoro-1,3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.

AB - A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF® solution, a copolymer of tetrafluoroethylene and 2,2-bis(trifluoroethylene)-4, 5-difluoro-1,3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.

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KW - Highly selective NO sensor

KW - Plasma

KW - RSNOs

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DO - 10.1016/j.cclet.2011.11.003

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JO - Chinese Chemical Letters

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Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor

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Keywords

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