Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li; Zhen Wang; Vy M. Dong; Xiao Hui Yang

doi:10.1021/jacs.2c12779

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Qi Li
, Zhen Wang
, Vy M. Dong^*
, Xiao Hui Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

Original language	English
Pages (from-to)	3909-3914
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	145
Issue number	7
DOIs	https://doi.org/10.1021/jacs.2c12779
Publication status	Published - 22 Feb 2023
Externally published	Yes

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10.1021/jacs.2c12779

Cite this

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abstract = "As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.",

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AU - Li, Qi

AU - Wang, Zhen

AU - Dong, Vy M.

AU - Yang, Xiao Hui

PY - 2023/2/22

Y1 - 2023/2/22

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AB - As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.

UR - https://www.scopus.com/pages/publications/85148034381

U2 - 10.1021/jacs.2c12779

DO - 10.1021/jacs.2c12779

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JF - Journal of the American Chemical Society

IS - 7

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Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

Abstract

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