Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Shao Feng Lu; Da Ming Du; Jiaxi Xu

doi:10.1021/ol060586f

Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Shao Feng Lu
, Da Ming Du^*
, Jiaxi Xu

^*Corresponding author for this work

Peking University

Research output: Contribution to journal › Article › peer-review

183 Citations (Scopus)

Abstract

A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)₂ as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

Original language	English
Pages (from-to)	2115-2118
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/ol060586f
Publication status	Published - 11 May 2006
Externally published	Yes

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10.1021/ol060586f

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title = "Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex",

abstract = "A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99\%) and high enantioselectivities (up to 98\% ee).",

author = "Lu, \{Shao Feng\} and Du, \{Da Ming\} and Jiaxi Xu",

year = "2006",

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doi = "10.1021/ol060586f",

language = "English",

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pages = "2115--2118",

journal = "Organic Letters",

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T1 - Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

AU - Lu, Shao Feng

AU - Du, Da Ming

AU - Xu, Jiaxi

PY - 2006/5/11

Y1 - 2006/5/11

N2 - A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

AB - A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

UR - https://www.scopus.com/pages/publications/33744757023

U2 - 10.1021/ol060586f

DO - 10.1021/ol060586f

M3 - Article

AN - SCOPUS:33744757023

SN - 1523-7060

VL - 8

SP - 2115

EP - 2118

JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Abstract

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