Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Shao Feng Lu; Da Ming Du; Jiaxi Xu

doi:10.1021/ol060586f

Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Shao Feng Lu, Da Ming Du^*, Jiaxi Xu

^*Corresponding author for this work

Peking University

Research output: Contribution to journal › Article › peer-review

180 Citations (Scopus)

Abstract

A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)₂ as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

Original language	English
Pages (from-to)	2115-2118
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/ol060586f
Publication status	Published - 11 May 2006
Externally published	Yes

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10.1021/ol060586f

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title = "Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex",

abstract = "A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99\%) and high enantioselectivities (up to 98\% ee).",

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year = "2006",

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AU - Lu, Shao Feng

AU - Du, Da Ming

AU - Xu, Jiaxi

PY - 2006/5/11

Y1 - 2006/5/11

N2 - A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

AB - A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis-(oxazoline)-Zn(OTf)2 as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).

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M3 - Article

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VL - 8

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JO - Organic Letters

JF - Organic Letters

IS - 10

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Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex

Abstract

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