Electrochemical properties and self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid

Chuan Wan Wei; Juan Li; You Nian Liu

doi:10.3969/j.issn.1001-4861.2013.00.007

Electrochemical properties and self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid

Chuan Wan Wei, Juan Li, You Nian Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid, Fc-KLVFF, is studied. Fc-KLVFF can self-assemble into nanotubes in methanol, as confirmed by transmission electron microscopy. The secondary structure of the nanotubes is characterized by FT-IR, fluorescence spectroscopy and UV-Visible spectroscopy, which indicate the important role of aromatic π- π stacking interactions between phenylalanine residues in driving β-sheet self-assembly. The electrochemical results showed that the Fc-KLVFF exhibits a pair of well-defined redox waves at oxidation potential (E_a) of 0.626 V and reduction potential (E_c) of 0.544 V, respectively, and the ratio of I_pa/ I_pc is 1.08. Finally, the model for the self-assembly ofFc-KLVFF is proposed.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Chinese Journal of Inorganic Chemistry
Volume	29
Issue number	1
DOIs	https://doi.org/10.3969/j.issn.1001-4861.2013.00.007
Publication status	Published - 2013
Externally published	Yes

Keywords

Beta-amyloid
Electrochemistry
Ferrocene
TEM

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10.3969/j.issn.1001-4861.2013.00.007

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title = "Electrochemical properties and self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid",

abstract = "The self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid, Fc-KLVFF, is studied. Fc-KLVFF can self-assemble into nanotubes in methanol, as confirmed by transmission electron microscopy. The secondary structure of the nanotubes is characterized by FT-IR, fluorescence spectroscopy and UV-Visible spectroscopy, which indicate the important role of aromatic π- π stacking interactions between phenylalanine residues in driving β-sheet self-assembly. The electrochemical results showed that the Fc-KLVFF exhibits a pair of well-defined redox waves at oxidation potential (Ea) of 0.626 V and reduction potential (Ec) of 0.544 V, respectively, and the ratio of Ipa/ Ipc is 1.08. Finally, the model for the self-assembly ofFc-KLVFF is proposed.",

keywords = "Beta-amyloid, Electrochemistry, Ferrocene, TEM",

author = "Wei, {Chuan Wan} and Juan Li and Liu, {You Nian}",

year = "2013",

doi = "10.3969/j.issn.1001-4861.2013.00.007",

language = "English",

volume = "29",

pages = "45--49",

journal = "Chinese Journal of Inorganic Chemistry",

issn = "1001-4861",

publisher = "Chinese Chemical Society",

number = "1",

}

TY - JOUR

T1 - Electrochemical properties and self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid

AU - Wei, Chuan Wan

AU - Li, Juan

AU - Liu, You Nian

PY - 2013

Y1 - 2013

N2 - The self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid, Fc-KLVFF, is studied. Fc-KLVFF can self-assemble into nanotubes in methanol, as confirmed by transmission electron microscopy. The secondary structure of the nanotubes is characterized by FT-IR, fluorescence spectroscopy and UV-Visible spectroscopy, which indicate the important role of aromatic π- π stacking interactions between phenylalanine residues in driving β-sheet self-assembly. The electrochemical results showed that the Fc-KLVFF exhibits a pair of well-defined redox waves at oxidation potential (Ea) of 0.626 V and reduction potential (Ec) of 0.544 V, respectively, and the ratio of Ipa/ Ipc is 1.08. Finally, the model for the self-assembly ofFc-KLVFF is proposed.

AB - The self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid, Fc-KLVFF, is studied. Fc-KLVFF can self-assemble into nanotubes in methanol, as confirmed by transmission electron microscopy. The secondary structure of the nanotubes is characterized by FT-IR, fluorescence spectroscopy and UV-Visible spectroscopy, which indicate the important role of aromatic π- π stacking interactions between phenylalanine residues in driving β-sheet self-assembly. The electrochemical results showed that the Fc-KLVFF exhibits a pair of well-defined redox waves at oxidation potential (Ea) of 0.626 V and reduction potential (Ec) of 0.544 V, respectively, and the ratio of Ipa/ Ipc is 1.08. Finally, the model for the self-assembly ofFc-KLVFF is proposed.

KW - Beta-amyloid

KW - Electrochemistry

KW - Ferrocene

KW - TEM

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U2 - 10.3969/j.issn.1001-4861.2013.00.007

DO - 10.3969/j.issn.1001-4861.2013.00.007

M3 - Article

AN - SCOPUS:84922686672

SN - 1001-4861

VL - 29

SP - 45

EP - 49

JO - Chinese Journal of Inorganic Chemistry

JF - Chinese Journal of Inorganic Chemistry

IS - 1

ER -

Electrochemical properties and self-assembly of ferrocene modified hydrophobic pentapeptide fragment of β-amyloid

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Keywords

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