Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3- carbonitrile derivatives

Yu Gao; Wen Yang; Da Ming Du

doi:10.1016/j.tetasy.2012.02.019

Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3- carbonitrile derivatives

Yu Gao
, Wen Yang
, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

The organocatalytic enantioselective tandem Michael addition-cyclization of malononitrile to nitroalkenes for the direct synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was investigated. Good yields and enantioselectivities (up to 91% ee) were achieved. This organocatalytic asymmetric tandem Michael addition-cyclization provides an efficient route toward the synthesis of optically active functionalized chromenes.

Original language	English
Pages (from-to)	339-344
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.tetasy.2012.02.019
Publication status	Published - 15 Mar 2012

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10.1016/j.tetasy.2012.02.019

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title = "Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3- carbonitrile derivatives",

abstract = "The organocatalytic enantioselective tandem Michael addition-cyclization of malononitrile to nitroalkenes for the direct synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was investigated. Good yields and enantioselectivities (up to 91\% ee) were achieved. This organocatalytic asymmetric tandem Michael addition-cyclization provides an efficient route toward the synthesis of optically active functionalized chromenes.",

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AU - Gao, Yu

AU - Yang, Wen

AU - Du, Da Ming

PY - 2012/3/15

Y1 - 2012/3/15

N2 - The organocatalytic enantioselective tandem Michael addition-cyclization of malononitrile to nitroalkenes for the direct synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was investigated. Good yields and enantioselectivities (up to 91% ee) were achieved. This organocatalytic asymmetric tandem Michael addition-cyclization provides an efficient route toward the synthesis of optically active functionalized chromenes.

AB - The organocatalytic enantioselective tandem Michael addition-cyclization of malononitrile to nitroalkenes for the direct synthesis of chiral 2-amino-4H-chromene-3-carbonitrile derivatives was investigated. Good yields and enantioselectivities (up to 91% ee) were achieved. This organocatalytic asymmetric tandem Michael addition-cyclization provides an efficient route toward the synthesis of optically active functionalized chromenes.

UR - https://www.scopus.com/pages/publications/84860286272

U2 - 10.1016/j.tetasy.2012.02.019

DO - 10.1016/j.tetasy.2012.02.019

M3 - Article

AN - SCOPUS:84860286272

SN - 0957-4166

VL - 23

SP - 339

EP - 344

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 5

ER -

Efficient organocatalytic asymmetric synthesis of 2-amino-4H-chromene-3- carbonitrile derivatives

Abstract

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