Efficient enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf)2 complexes

Jiahuan Peng; Da Ming Du

doi:10.1039/c3ra45438j

Efficient enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf)₂ complexes

Jiahuan Peng, Da Ming Du^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

An efficient highly enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf) ₂ complexes has been developed. The corresponding products could be obtained with good to excellent enantioselectivities (up to > 99% ee) in excellent yields by utilizing N-fluorobisbenzenesulphonimide (NFSI) as fluorination reagent.

Original language	English
Pages (from-to)	2061-2067
Number of pages	7
Journal	RSC Advances
Volume	4
Issue number	4
DOIs	https://doi.org/10.1039/c3ra45438j
Publication status	Published - 2014

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10.1039/c3ra45438j

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title = "Efficient enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf)2 complexes",

abstract = "An efficient highly enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf) 2 complexes has been developed. The corresponding products could be obtained with good to excellent enantioselectivities (up to > 99% ee) in excellent yields by utilizing N-fluorobisbenzenesulphonimide (NFSI) as fluorination reagent.",

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N2 - An efficient highly enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf) 2 complexes has been developed. The corresponding products could be obtained with good to excellent enantioselectivities (up to > 99% ee) in excellent yields by utilizing N-fluorobisbenzenesulphonimide (NFSI) as fluorination reagent.

AB - An efficient highly enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf) 2 complexes has been developed. The corresponding products could be obtained with good to excellent enantioselectivities (up to > 99% ee) in excellent yields by utilizing N-fluorobisbenzenesulphonimide (NFSI) as fluorination reagent.

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DO - 10.1039/c3ra45438j

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Efficient enantioselective fluorination of β-keto esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf)₂ complexes

Abstract

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