Effective chemical constituent's confirmation of extracting solution from herbs and their gene targets

  • Wen Jin
  • , Qingqiong Deng
  • , Meiying Niu
  • , Liping Hu
  • , Aijuan Liu
  • , Guihua Tian
  • , Jianqiu Lu
  • , Mingquan Zhou
  • , Ghulam Murtaza*
  • , Haiyan Jiang
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ixeris sonchifolia Hance, a normal perennial herb, has effects on appendicitis, headache, menstruation, blood circulation, blood stasis, pain, fibrinolytic enzymes, thrombus formation, coronary artery, myocardial infarct size, PGI2, ET, TXA2, TNF-,αIL-6 and IL-8, etc . However, there was no full coverage about the molecular basis and gene targets of Ixeris sonchifolia injection. PubChem Database and DAVID Database had been used conjunctively to detect the gene IDs, gene targets and their functions. There were 3008 genes found in the final results, 16 kinds of definite functions had been detected, 9 of which had been proved and the effects were focused on the psychological, immune, neurological, metabolic, cardiovascular and cancer functions. Ixeris sonchifolia had a wide effects on various symptoms, which had been reported by previous experiments and verified by this research; however its influences on aging, chemdependency, developmental, normalvariation, reproduction, pharmacogenomic and psychologic functions should be confirmed in the future experiments.

Original languageEnglish
Pages (from-to)75-94
Number of pages20
JournalGenetika
Volume46
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Database
  • Functions
  • Gene targets
  • Information integration
  • Ixeris sonchifolia hance

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