Effect of elaeagnus conferta roxb (elaeagnaceae) dry fruit on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in mice

Chongming Wu, Rongji Dai, Jingmiao Bai, Yan Chen, Yuhong Yu, Weiwei Meng*, Yulin Deng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Purposes: To determine the effect of Elaeagnus conferta Roxb dry fruit powder (ECR) on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Methods: In a randomized controlled study, acute alcohol intoxication was induced in mice with Hongxing liquor containing 65% v/v ethanol orally. The effect of ECR on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in the mice was then investigated. Results: A 30-min pretreatment with ECR at 400 and 800 mg/kg led to a faster clearance of blood alcohol after the alcohol ingestion. The concentration of blood alcohol at 4 h after alcohol ingestion decreased by 21.2% in mice pretreated with 800 mg/kg ECR. The activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were enhanced by ECR. Conclusion: These results suggest that pretreatment with ECR might stimulate the clearance of blood alcohol by increasing the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase. Copy; Pharmacotherapy Group.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalTropical Journal of Pharmaceutical Research
Volume10
Issue number6
Publication statusPublished - Dec 2011

Keywords

  • Alcohol dehydrogenase (ADH)
  • Aldehyde dehydrogenase (ALDH)
  • Blood alcohol clearance
  • Elaeagnus conferta roxb

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