Abstract
Purposes: To determine the effect of Elaeagnus conferta Roxb dry fruit powder (ECR) on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Methods: In a randomized controlled study, acute alcohol intoxication was induced in mice with Hongxing liquor containing 65% v/v ethanol orally. The effect of ECR on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in the mice was then investigated. Results: A 30-min pretreatment with ECR at 400 and 800 mg/kg led to a faster clearance of blood alcohol after the alcohol ingestion. The concentration of blood alcohol at 4 h after alcohol ingestion decreased by 21.2% in mice pretreated with 800 mg/kg ECR. The activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were enhanced by ECR. Conclusion: These results suggest that pretreatment with ECR might stimulate the clearance of blood alcohol by increasing the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase. Copy; Pharmacotherapy Group.
Original language | English |
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Pages (from-to) | 761-766 |
Number of pages | 6 |
Journal | Tropical Journal of Pharmaceutical Research |
Volume | 10 |
Issue number | 6 |
Publication status | Published - Dec 2011 |
Keywords
- Alcohol dehydrogenase (ADH)
- Aldehyde dehydrogenase (ALDH)
- Blood alcohol clearance
- Elaeagnus conferta roxb