Abstract
Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 1056-1065 |
| Number of pages | 10 |
| Journal | Computer Methods in Biomechanics and Biomedical Engineering |
| Volume | 20 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 27 Jul 2017 |
Keywords
- Photodynamic therapy
- computer simulation
- hypoxia
- photothermolysis
- singlet oxygen
Fingerprint
Dive into the research topics of 'Dynamic model of vascular-targeted photodynamic therapy'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver