Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen; Li Chen; Xuemei Yao; Zhe Zhang; Chaoliang He; Jingping Zhang; Xuesi Chen

doi:10.1039/c4cc00016a

Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen
, Li Chen^*
, Xuemei Yao
, Zhe Zhang
, Chaoliang He
, Jingping Zhang
, Xuesi Chen

^*Corresponding author for this work

Northeast Normal University
CAS - Changchun Institute of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

Original language	English
Pages (from-to)	3789-3791
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	29
DOIs	https://doi.org/10.1039/c4cc00016a
Publication status	Published - 13 Mar 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c4cc00016a

Cite this

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abstract = "Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.",

author = "Xiaofei Chen and Li Chen and Xuemei Yao and Zhe Zhang and Chaoliang He and Jingping Zhang and Xuesi Chen",

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AU - Chen, Xiaofei

AU - Chen, Li

AU - Yao, Xuemei

AU - Zhang, Zhe

AU - He, Chaoliang

AU - Zhang, Jingping

AU - Chen, Xuesi

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

AB - Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

UR - https://www.scopus.com/pages/publications/84896281552

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DO - 10.1039/c4cc00016a

M3 - Article

C2 - 24519486

AN - SCOPUS:84896281552

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VL - 50

SP - 3789

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JO - Chemical Communications

JF - Chemical Communications

IS - 29

ER -

Dual responsive supramolecular nanogels for intracellular drug delivery

Abstract

UN SDGs

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