Double-pronged Antimicrobial Agents based on a Donor-π-Acceptor Type Aggregation-Induced Emission Luminogen

Yifan Wu; Jiangao Li; Zipeng Shen; Deliang Wang; Ruihua Dong; Jiangjiang Zhang; Yinzhen Pan; Ying Li; Dong Wang; Ben Zhong Tang

doi:10.1002/anie.202212386

Double-pronged Antimicrobial Agents based on a Donor-π-Acceptor Type Aggregation-Induced Emission Luminogen

Yifan Wu, Jiangao Li, Zipeng Shen, Deliang Wang, Ruihua Dong, Jiangjiang Zhang, Yinzhen Pan, Ying Li^*, Dong Wang^*, Ben Zhong Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-π-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh-treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.

Original language	English
Article number	e202212386
Journal	Angewandte Chemie - International Edition
Volume	61
Issue number	47
DOIs	https://doi.org/10.1002/anie.202212386
Publication status	Published - 21 Nov 2022
Externally published	Yes

Keywords

Aggregation-Induced Emission
Host-Directed Antibacterial Therapies
Lysosome
Macrophage
Multidrug-Resistant Bacteria

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10.1002/anie.202212386

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title = "Double-pronged Antimicrobial Agents based on a Donor-π-Acceptor Type Aggregation-Induced Emission Luminogen",

abstract = "Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-π-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh-treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.",

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author = "Yifan Wu and Jiangao Li and Zipeng Shen and Deliang Wang and Ruihua Dong and Jiangjiang Zhang and Yinzhen Pan and Ying Li and Dong Wang and Tang, {Ben Zhong}",

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AU - Wu, Yifan

AU - Li, Jiangao

AU - Shen, Zipeng

AU - Wang, Deliang

AU - Dong, Ruihua

AU - Zhang, Jiangjiang

AU - Pan, Yinzhen

AU - Li, Ying

AU - Wang, Dong

AU - Tang, Ben Zhong

PY - 2022/11/21

Y1 - 2022/11/21

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AB - Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-π-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh-treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.

KW - Aggregation-Induced Emission

KW - Host-Directed Antibacterial Therapies

KW - Lysosome

KW - Macrophage

KW - Multidrug-Resistant Bacteria

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Double-pronged Antimicrobial Agents based on a Donor-π-Acceptor Type Aggregation-Induced Emission Luminogen

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Keywords

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