Abstract
This study presents a novel ion source for direct integration of digital microfluidics (DMF) with a miniature mass spectrometer (mini-MS) for online biochemical analysis. Ion source is structured with double capillary adapted to a spyhole. Key operational parameters are systematically optimized to maximize ionization efficiency and enhance signal intensity. The system shows quantitative capability and a limit-of-detection of 1 ng/mL, comparable to nanospray electrospray ionization (nanoESI). By seamlessly combining the automation and versatility of DMF with the highly sensitive MS, the proposed platform establishes a robust foundation for rapid real-time biochemical assays.
| Original language | English |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers |
| Issue number | 2025 |
| DOIs | |
| Publication status | Published - 2025 |
| Event | 23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025 - Orlando, United States Duration: 29 Jun 2025 → 3 Jul 2025 |
Keywords
- analytical chemistry
- Digital Microfluidics
- mass spectrometry
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