Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography

Y. T. Pan; Z. G. Wang; Z. L. Wu; A. Jain; H. K. Xie

doi:10.1109/iembs.2005.1616175

Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography

Y. T. Pan^*
, Z. G. Wang
, Z. L. Wu
, A. Jain
, H. K. Xie

^*Corresponding author for this work

Stony Brook University
University of Florida

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Citations (Scopus)

Abstract

We present some of the recent technological advances in our MEMS-based endoscopic optical coherence tomography (OCT) system for the enhancement of image fidelity and diagnosis. The endoscopic OCT system permits simultaneous cross-sectional OCT imaging and en face white-light visual guidance as well as fluorescence imaging guidance. The transverse and axial resolutions of the OCT scope are roughly 12μm and 10μm, respectively, and the axial resolution can be enhanced to 3um if connecting it to our recent custom sub-8fs Ti:Al ₂O₃ laser. To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90% sensitivity and specificity. Applications in imaging of bladder functions and engineering tissue growth are demonstrated.

Original language	English
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	7217-7220
Number of pages	4
ISBN (Print)	0780387406, 9780780387409
DOIs	https://doi.org/10.1109/iembs.2005.1616175
Publication status	Published - 2005
Externally published	Yes
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: 1 Sept 2005 → 4 Sept 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Conference

Conference	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country/Territory	China
City	Shanghai
Period	1/09/05 → 4/09/05

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/iembs.2005.1616175

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Pan, Y. T., Wang, Z. G., Wu, Z. L., Jain, A., & Xie, H. K. (2005). Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 7217-7220). Article 1616175 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/iembs.2005.1616175

Pan, Y. T. ; Wang, Z. G. ; Wu, Z. L. et al. / Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc., 2005. pp. 7217-7220 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

@inproceedings{6cecbe55e78f4a5d990e2ae261bb86e7,

title = "Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography",

abstract = "We present some of the recent technological advances in our MEMS-based endoscopic optical coherence tomography (OCT) system for the enhancement of image fidelity and diagnosis. The endoscopic OCT system permits simultaneous cross-sectional OCT imaging and en face white-light visual guidance as well as fluorescence imaging guidance. The transverse and axial resolutions of the OCT scope are roughly 12μm and 10μm, respectively, and the axial resolution can be enhanced to 3um if connecting it to our recent custom sub-8fs Ti:Al 2O3 laser. To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90\% sensitivity and specificity. Applications in imaging of bladder functions and engineering tissue growth are demonstrated.",

author = "Pan, \{Y. T.\} and Wang, \{Z. G.\} and Wu, \{Z. L.\} and A. Jain and Xie, \{H. K.\}",

year = "2005",

doi = "10.1109/iembs.2005.1616175",

language = "English",

isbn = "0780387406",

series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "7217--7220",

booktitle = "Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005",

address = "United States",

note = "2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 ; Conference date: 01-09-2005 Through 04-09-2005",

}

Pan, YT, Wang, ZG, Wu, ZL, Jain, A & Xie, HK 2005, Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616175, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, Institute of Electrical and Electronics Engineers Inc., pp. 7217-7220, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 1/09/05. https://doi.org/10.1109/iembs.2005.1616175

Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography. / Pan, Y. T.; Wang, Z. G.; Wu, Z. L. et al.
Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc., 2005. p. 7217-7220 1616175 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography

AU - Pan, Y. T.

AU - Wang, Z. G.

AU - Wu, Z. L.

AU - Jain, A.

AU - Xie, H. K.

PY - 2005

Y1 - 2005

N2 - We present some of the recent technological advances in our MEMS-based endoscopic optical coherence tomography (OCT) system for the enhancement of image fidelity and diagnosis. The endoscopic OCT system permits simultaneous cross-sectional OCT imaging and en face white-light visual guidance as well as fluorescence imaging guidance. The transverse and axial resolutions of the OCT scope are roughly 12μm and 10μm, respectively, and the axial resolution can be enhanced to 3um if connecting it to our recent custom sub-8fs Ti:Al 2O3 laser. To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90% sensitivity and specificity. Applications in imaging of bladder functions and engineering tissue growth are demonstrated.

AB - We present some of the recent technological advances in our MEMS-based endoscopic optical coherence tomography (OCT) system for the enhancement of image fidelity and diagnosis. The endoscopic OCT system permits simultaneous cross-sectional OCT imaging and en face white-light visual guidance as well as fluorescence imaging guidance. The transverse and axial resolutions of the OCT scope are roughly 12μm and 10μm, respectively, and the axial resolution can be enhanced to 3um if connecting it to our recent custom sub-8fs Ti:Al 2O3 laser. To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90% sensitivity and specificity. Applications in imaging of bladder functions and engineering tissue growth are demonstrated.

UR - https://www.scopus.com/pages/publications/33846918918

U2 - 10.1109/iembs.2005.1616175

DO - 10.1109/iembs.2005.1616175

M3 - Conference contribution

AN - SCOPUS:33846918918

SN - 0780387406

SN - 9780780387409

T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SP - 7217

EP - 7220

BT - Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005

PB - Institute of Electrical and Electronics Engineers Inc.

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Y2 - 1 September 2005 through 4 September 2005

ER -

Pan YT, Wang ZG, Wu ZL, Jain A, Xie HK. Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. Institute of Electrical and Electronics Engineers Inc. 2005. p. 7217-7220. 1616175. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). doi: 10.1109/iembs.2005.1616175

Diagnosis of biological tissue morphology and function with endoscopic optical coherence tomography

Abstract

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