TY - GEN
T1 - Development of an Electrochemical Chiral Sensor Based on UiO-66-NH₂-L-Pro Metal-Organic Framework for Enantioselective Detection of Threonine
AU - Ma, Yizhuo
AU - Abbasi, Maria
AU - Gong, Jiale
AU - Huang, Jia
AU - Ma, Shengnan
AU - Mounir, Herhira Taha Siredj
AU - Zhang, Niu
AU - Lei, Runhong
AU - Li, Yongrui
AU - Geng, Lina
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2026.
PY - 2026
Y1 - 2026
N2 - Chiral identification has significant research value in fields such as food and medicine, mainly due to the specific expression of biomolecular enantiomers. This study focused on the enantioselective recognition problem of L-/D-threonine and developed a novel chiral electrochemical sensor. The specific approach was to modify L-proline onto the surface of UiO-66-NH₂ to form the UiO-66-NH₂ -L-Pro complex. The preparation process adopted solvothermal technology combined with ultrasonic refining. The FT-IR results confirmed that both the Zr-O bonding performance and the framework coordination degree were significantly optimized under this ideal condition, and the differential pulse voltammetry (DPV) was used to evaluate the chiral sensing characteristics of this material. The L-threonine and D-threonine had recovery rates of 21.0–106.3 and 45.5–97.8 in percentage, which implied the applicability of the sensor in complex bio-samples. In a straightforward and efficient way, this modification method increases interface exposure and response efficiency. The sensor has great potential for use in food safety monitoring, pharmaceutical quality control, and clinical diagnostics. This strategy will be expanded to other chiral biomolecules in future research, and sensor stability and sensitivity will be improved for real-world applications.
AB - Chiral identification has significant research value in fields such as food and medicine, mainly due to the specific expression of biomolecular enantiomers. This study focused on the enantioselective recognition problem of L-/D-threonine and developed a novel chiral electrochemical sensor. The specific approach was to modify L-proline onto the surface of UiO-66-NH₂ to form the UiO-66-NH₂ -L-Pro complex. The preparation process adopted solvothermal technology combined with ultrasonic refining. The FT-IR results confirmed that both the Zr-O bonding performance and the framework coordination degree were significantly optimized under this ideal condition, and the differential pulse voltammetry (DPV) was used to evaluate the chiral sensing characteristics of this material. The L-threonine and D-threonine had recovery rates of 21.0–106.3 and 45.5–97.8 in percentage, which implied the applicability of the sensor in complex bio-samples. In a straightforward and efficient way, this modification method increases interface exposure and response efficiency. The sensor has great potential for use in food safety monitoring, pharmaceutical quality control, and clinical diagnostics. This strategy will be expanded to other chiral biomolecules in future research, and sensor stability and sensitivity will be improved for real-world applications.
KW - Chirality
KW - Differential Pulse Voltammetry
KW - Electrochemical Chiral Sensor
KW - Metal Organic Framework Threonine
UR - https://www.scopus.com/pages/publications/105045567033
U2 - 10.1007/978-981-95-6739-3_5
DO - 10.1007/978-981-95-6739-3_5
M3 - Conference contribution
AN - SCOPUS:105045567033
SN - 9789819567386
T3 - Communications in Computer and Information Science
SP - 62
EP - 76
BT - Advanced Computational Intelligence and Intelligent Informatics - 9th International Workshop, IWACIII 2025, Proceedings
A2 - Ma, Hongbin
A2 - Xin, Bin
A2 - She, Jinhua
A2 - Lu, Guiping
PB - Springer Science and Business Media Deutschland GmbH
T2 - 9th International Workshop on Advanced Computational Intelligence and Intelligent Informatics, IWACIII 2025
Y2 - 31 October 2025 through 4 November 2025
ER -