Dehydroxyselenocyanation of alcohols under grinding conditions

Xinzhe Zhao; Hongquan Yin; Fu Xue Chen

doi:10.1039/d5ob00305a

Dehydroxyselenocyanation of alcohols under grinding conditions

Xinzhe Zhao
, Hongquan Yin^*
, Fu Xue Chen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A novel strategy for dehydroxyselenocyanation of alcohols, utilizing a readily available electrophilic selenocyanating reagent N-selenocyanatophthalimide in combination with triphenylphosphine under grinding conditions within 2 min at room temperature was developed. This solvent-free methodology is time-efficient and features a broad substrate scope, enabling the late-stage functionalization of diverse pharmaceutical molecules and natural products.

Original language	English
Pages (from-to)	4660-4665
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	23
Issue number	19
DOIs	https://doi.org/10.1039/d5ob00305a
Publication status	Published - 17 Apr 2025

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title = "Dehydroxyselenocyanation of alcohols under grinding conditions",

abstract = "A novel strategy for dehydroxyselenocyanation of alcohols, utilizing a readily available electrophilic selenocyanating reagent N-selenocyanatophthalimide in combination with triphenylphosphine under grinding conditions within 2 min at room temperature was developed. This solvent-free methodology is time-efficient and features a broad substrate scope, enabling the late-stage functionalization of diverse pharmaceutical molecules and natural products.",

author = "Xinzhe Zhao and Hongquan Yin and Chen, \{Fu Xue\}",

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AU - Yin, Hongquan

AU - Chen, Fu Xue

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N2 - A novel strategy for dehydroxyselenocyanation of alcohols, utilizing a readily available electrophilic selenocyanating reagent N-selenocyanatophthalimide in combination with triphenylphosphine under grinding conditions within 2 min at room temperature was developed. This solvent-free methodology is time-efficient and features a broad substrate scope, enabling the late-stage functionalization of diverse pharmaceutical molecules and natural products.

AB - A novel strategy for dehydroxyselenocyanation of alcohols, utilizing a readily available electrophilic selenocyanating reagent N-selenocyanatophthalimide in combination with triphenylphosphine under grinding conditions within 2 min at room temperature was developed. This solvent-free methodology is time-efficient and features a broad substrate scope, enabling the late-stage functionalization of diverse pharmaceutical molecules and natural products.

UR - https://www.scopus.com/pages/publications/105003666104

U2 - 10.1039/d5ob00305a

DO - 10.1039/d5ob00305a

M3 - Article

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AN - SCOPUS:105003666104

SN - 1477-0520

VL - 23

SP - 4660

EP - 4665

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 19

ER -

Dehydroxyselenocyanation of alcohols under grinding conditions

Abstract

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