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Cytotoxicity and antibacterial activity of chitosan-organic rectorite intercalated nanofibrous mats

  • Jing Du
  • , Xueyong Li
  • , Chen Yang
  • , Wei Li
  • , Weijuan Huang
  • , Rong Huang
  • , Xue Zhou*
  • , Hongbing Deng
  • *Corresponding author for this work
  • Huazhong University of Science and Technology
  • Huazhong Agricultural University
  • Tangdu Hospital, Fourth Military Medical University
  • Wuhan University

Research output: Contribution to journalArticlepeer-review

Abstract

The chitosan (CS)-organic rectorite (OREC) composites are prepared with the method of solution intercalation. Electrospun nanofibrous mats are made from intercalated CS-OREC composites at different mass ratios. The properties and structure of intercalated CS-OREC can be verified by small angle X-ray diffraction (SAXRD) and transmission electron microscopy (TEM) micrographs. Energy dispersive X-ray (EDX) spectroscopy and fourier transform infrared (FT-IR) spectra reveal that OREC presents in the composite nanofibrous mats. The MTT assay indicates that the cytotoxicity of the intercalated CS-OREC nanofibrous mats is low. Besides, the content of OREC in nanofibrous mats has a significant influence on the viability of cells. Antibacterial test confirms that OREC can increase the inhibition rate of the nanofibrous mats against Escherichia coli.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalCurrent Nanoscience
Volume9
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Antibacterial activity
  • Bacterial activity
  • Chitosan
  • Cytotoxicity
  • Electrospinning
  • Intercalation
  • Organic rectorite

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