TY - JOUR
T1 - Cortical dynamics and network alterations in Parkinson’s disease with mild cognitive impairment
T2 - TMS-EEG study of the posterior parietal cortex
AU - Pei, Guangying
AU - Yang, Xiao
AU - Liu, Han
AU - Hu, Mengxuan
AU - Chen, Keke
AU - Xue, Cuiping
AU - Jin, Zhaohui
AU - Wang, Li
AU - Zhang, Chunyu
AU - Fang, Boyan
AU - Yan, Tianyi
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2026/12
Y1 - 2026/12
N2 - Individuals with mild cognitive impairment (MCI) in Parkinson’s disease (PD) are significantly susceptible to developing dementia. Investigating cortical dynamics within the posterior parietal cortex (PPC) may elucidate the mechanisms underlying cognitive decline in PD. Using combined transcranial magnetic stimulation-electroencephalography, this study assessed cortical excitability, time-frequency oscillations, and functional network dynamics after stimulation of the right PPC in 45 PD patients (23 with MCI, 22 with normal cognition). Results showed that PD-MCI patients exhibited increased TMS-evoked potentials across the frontal-parietal-occipital cortex compared to cognitively normal PD patients, accompanied by enhanced theta and alpha oscillation synchronization. Functional connectivity analysis revealed higher global efficiency and lower average shortest path length within theta-band frontoparietal networks in PD-MCI, which correlated with poorer cognitive performance. These results highlight hyperactive cortical responses and hyperconnected low-frequency brain networks in PD-MCI following right PPC stimulation, implicating the PPC as a potential intervention target to mitigate cognitive decline in PD.
AB - Individuals with mild cognitive impairment (MCI) in Parkinson’s disease (PD) are significantly susceptible to developing dementia. Investigating cortical dynamics within the posterior parietal cortex (PPC) may elucidate the mechanisms underlying cognitive decline in PD. Using combined transcranial magnetic stimulation-electroencephalography, this study assessed cortical excitability, time-frequency oscillations, and functional network dynamics after stimulation of the right PPC in 45 PD patients (23 with MCI, 22 with normal cognition). Results showed that PD-MCI patients exhibited increased TMS-evoked potentials across the frontal-parietal-occipital cortex compared to cognitively normal PD patients, accompanied by enhanced theta and alpha oscillation synchronization. Functional connectivity analysis revealed higher global efficiency and lower average shortest path length within theta-band frontoparietal networks in PD-MCI, which correlated with poorer cognitive performance. These results highlight hyperactive cortical responses and hyperconnected low-frequency brain networks in PD-MCI following right PPC stimulation, implicating the PPC as a potential intervention target to mitigate cognitive decline in PD.
UR - https://www.scopus.com/pages/publications/105026771106
U2 - 10.1038/s41531-025-01186-7
DO - 10.1038/s41531-025-01186-7
M3 - Article
AN - SCOPUS:105026771106
SN - 2373-8057
VL - 12
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 6
ER -