TY - JOUR
T1 - Coronary artery calcification in Takayasu’s arteritis
T2 - clinical characteristics and risk factors
AU - Yang, Shiyu
AU - Zhang, Nan
AU - Zhao, Wenjing
AU - Du, Juan
AU - Gao, Na
AU - Shi, Xuemei
AU - Zhang, Yaxin
AU - Liu, Jiayi
AU - Pan, Lili
N1 - Publisher Copyright:
© Copyright Clinical and Experimental Rheumatology 2024.
PY - 2024/4
Y1 - 2024/4
N2 - Objective Coronary artery calcification (CAC) is frequently observed in Takayasu’s arteritis (TAK). Our objective is to calculate the prevalence and severity of CAC in TAK, while evaluating the influence of traditional cardiovascular risk factors, glucocorticoid exposure, and disease activity on CAC. Methods This retrospective study involved 155 TAK patients. We measured the Agatston score by coronary computed tomography angiography (CCTA) and categorised all patients into groups with or without CAC (41 vs. 114) to compare clinical characteristics and ancillary findings between the two groups. Results Among the TAK patients, a total of 41 TAK patients (26.45%) exhibited CAC. Age of onset, disease duration, history of hypertension, history of hyperlipidaemia, Numano V and glucocorticoid use emerged as the independent risk factors for developing CAC in TAK (OR [95% CI] 1.084[1.028–1.142], p=0.003; 1.005 [1.001–1.010], p=0.020; 4.792 [1.713–13.411], p=0.003; 4.199 [1.087–16.219], p=0.037; 3.287 [1.070–10.100], p=0.038; 3.558[1.269–9.977], p=0.016). Nonetheless, CAC was not associated with disease activity. Moreover, the extent of calcification score in TAK showed a positive correlation with the number of traditional cardiovascular risk factors. Conclusion We recommend CCTA screening for Numano V classified TAK patients. Glucocorticoid usage significantly escalates the risk of CAC. Therefore, in cases of effectively controlled disease, the inclusion of immunosuppressants aimed at reducing glucocorticoid dosage is advisable.
AB - Objective Coronary artery calcification (CAC) is frequently observed in Takayasu’s arteritis (TAK). Our objective is to calculate the prevalence and severity of CAC in TAK, while evaluating the influence of traditional cardiovascular risk factors, glucocorticoid exposure, and disease activity on CAC. Methods This retrospective study involved 155 TAK patients. We measured the Agatston score by coronary computed tomography angiography (CCTA) and categorised all patients into groups with or without CAC (41 vs. 114) to compare clinical characteristics and ancillary findings between the two groups. Results Among the TAK patients, a total of 41 TAK patients (26.45%) exhibited CAC. Age of onset, disease duration, history of hypertension, history of hyperlipidaemia, Numano V and glucocorticoid use emerged as the independent risk factors for developing CAC in TAK (OR [95% CI] 1.084[1.028–1.142], p=0.003; 1.005 [1.001–1.010], p=0.020; 4.792 [1.713–13.411], p=0.003; 4.199 [1.087–16.219], p=0.037; 3.287 [1.070–10.100], p=0.038; 3.558[1.269–9.977], p=0.016). Nonetheless, CAC was not associated with disease activity. Moreover, the extent of calcification score in TAK showed a positive correlation with the number of traditional cardiovascular risk factors. Conclusion We recommend CCTA screening for Numano V classified TAK patients. Glucocorticoid usage significantly escalates the risk of CAC. Therefore, in cases of effectively controlled disease, the inclusion of immunosuppressants aimed at reducing glucocorticoid dosage is advisable.
KW - Takayasu’s arteritis
KW - coronary artery calcification
KW - glucocorticoid
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85191896849&partnerID=8YFLogxK
U2 - 10.55563/clinexprheumatol/ypq2lj
DO - 10.55563/clinexprheumatol/ypq2lj
M3 - Article
C2 - 38607693
AN - SCOPUS:85191896849
SN - 0392-856X
VL - 42
SP - 843
EP - 851
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
IS - 4
ER -