Constructing Energetic Tetrazoles via a Flexible Methylene Bridge

Jinyu Chang; Qi Sun; Ning Ding; Yanda Jiang; Nishan Yao; Xudong Xu; Baojing Tian; Shenghua Li; Siping Pang

doi:10.1021/acs.orglett.5c04223

Constructing Energetic Tetrazoles via a Flexible Methylene Bridge

Jinyu Chang
, Qi Sun^*
, Ning Ding
, Yanda Jiang
, Nishan Yao
, Xudong Xu
, Baojing Tian
, Shenghua Li^*
, Siping Pang^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we present a “flexible methylene bridge” strategy for designing tetrazole-based energetic materials. This approach enables structural modulation through two pathways: (1) solvent-induced bridge distortion to access different molecular configurations (compounds 3-α and 3-β) and (2) base-induced bridge cleavage to promote the formation of ionic salts (compounds 4 and 5). Our work not only provides a versatile method for conformational control but also highlights the practical promise of tetrazole-based high-energy compounds.

Original language	English
Pages (from-to)	12846-12850
Number of pages	5
Journal	Organic Letters
Volume	27
Issue number	46
DOIs	https://doi.org/10.1021/acs.orglett.5c04223
Publication status	Published - 21 Nov 2025
Externally published	Yes

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10.1021/acs.orglett.5c04223

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title = "Constructing Energetic Tetrazoles via a Flexible Methylene Bridge",

abstract = "In this study, we present a “flexible methylene bridge” strategy for designing tetrazole-based energetic materials. This approach enables structural modulation through two pathways: (1) solvent-induced bridge distortion to access different molecular configurations (compounds 3-α and 3-β) and (2) base-induced bridge cleavage to promote the formation of ionic salts (compounds 4 and 5). Our work not only provides a versatile method for conformational control but also highlights the practical promise of tetrazole-based high-energy compounds.",

author = "Jinyu Chang and Qi Sun and Ning Ding and Yanda Jiang and Nishan Yao and Xudong Xu and Baojing Tian and Shenghua Li and Siping Pang",

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T1 - Constructing Energetic Tetrazoles via a Flexible Methylene Bridge

AU - Chang, Jinyu

AU - Sun, Qi

AU - Ding, Ning

AU - Jiang, Yanda

AU - Yao, Nishan

AU - Xu, Xudong

AU - Tian, Baojing

AU - Li, Shenghua

AU - Pang, Siping

PY - 2025/11/21

Y1 - 2025/11/21

N2 - In this study, we present a “flexible methylene bridge” strategy for designing tetrazole-based energetic materials. This approach enables structural modulation through two pathways: (1) solvent-induced bridge distortion to access different molecular configurations (compounds 3-α and 3-β) and (2) base-induced bridge cleavage to promote the formation of ionic salts (compounds 4 and 5). Our work not only provides a versatile method for conformational control but also highlights the practical promise of tetrazole-based high-energy compounds.

AB - In this study, we present a “flexible methylene bridge” strategy for designing tetrazole-based energetic materials. This approach enables structural modulation through two pathways: (1) solvent-induced bridge distortion to access different molecular configurations (compounds 3-α and 3-β) and (2) base-induced bridge cleavage to promote the formation of ionic salts (compounds 4 and 5). Our work not only provides a versatile method for conformational control but also highlights the practical promise of tetrazole-based high-energy compounds.

UR - https://www.scopus.com/pages/publications/105022666918

U2 - 10.1021/acs.orglett.5c04223

DO - 10.1021/acs.orglett.5c04223

M3 - Article

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SN - 1523-7060

VL - 27

SP - 12846

EP - 12850

JO - Organic Letters

JF - Organic Letters

IS - 46

ER -

Constructing Energetic Tetrazoles via a Flexible Methylene Bridge

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