TY - JOUR
T1 - Cognitive processing of cluster headache patients
T2 - evidence from event-related potentials
AU - Wang, Rongfei
AU - Dong, Zhao
AU - Chen, Xiaoyan
AU - Liu, Ruozhuo
AU - Zhang, Mingjie
AU - Wu, Jinglong
AU - Yu, Shengyuan
N1 - Publisher Copyright:
© 2014, Wang et al.; licensee Springer.
PY - 2014
Y1 - 2014
N2 - Background: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache.Methods: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment.Results: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05).Conclusions: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH.
AB - Background: The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache.Methods: Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment.Results: P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05).Conclusions: These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH.
KW - Cluster headache
KW - Cognitive processing
KW - ERPs
KW - P3/P3d
UR - http://www.scopus.com/inward/record.url?scp=84919884597&partnerID=8YFLogxK
U2 - 10.1186/1129-2377-15-66
DO - 10.1186/1129-2377-15-66
M3 - Article
C2 - 25277954
AN - SCOPUS:84919884597
SN - 1129-2369
VL - 15
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 1
M1 - 66
ER -